Seroatlas · Human Serome Atlas

LY6G6D

Lymphocyte antigen 6 complex locus protein G6d

Also known as: C6orf23, G6D, Ly6-D, LY66D_HUMAN, MEGT1, NG25

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95868
Gene
LY6G6D
Ensembl
ENSG00000244355
Chromosome
6
Canonical length
133 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Secretome location
Intracellular and membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

This locus represents naturally occurring readthrough transcription between the neighboring LY6G6F (lymphocyte antigen 6 family member G6F) and LY6G6D (lymphocyte antigen 6 family member G6D) genes on chromosome 6. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

133 residues, UniProt reviewed canonical sequence.

>O95868|LY6G6D
     1  MKPQFVGILL SSLLGAALGN RMRCYNCGGS PSSSCKEAVT TCGEGRPQPG LEQIKLPGNP
    61  PVTLIHQHPA CVAAHHCNQV ETESVGDVTY PAHRDCYLGD LCNSAVASHV APAGILAAAA
   121  TALTCLLPGL WSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LY6G6D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • skin: 34 nTPM
  • seminal vesicle: 6.3 nTPM
  • colon: 5 nTPM
  • prostate: 3.3 nTPM
  • cervix: 2.2 nTPM
  • vagina: 1.5 nTPM

Single-cell type

  • platelets: 2.8 nCPM
  • neuroendocrine cells: 0.5 nCPM
  • suprabasal keratinocytes: 0.3 nCPM
  • breast secretory cells: 0.1 nCPM
  • megakaryocyte progenitors: 0.1 nCPM
  • prostatic glandular cells: 0.1 nCPM

Immune cell

  • intermediate monocyte: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.3 nTPM
  • basal ganglia: 0.2 nTPM
  • midbrain: 0.2 nTPM
  • spinal cord: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • cerebellum: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.26
gnomAD pLI
0.03
gnomAD missense Z
0.1

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LY6G6D as an antibody target. Whether an autoantibody or antibody against LY6G6D could matter depends on whether native LY6G6D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LY6G6D is annotated at the cell surface, where native LY6G6D is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LY6G6D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LY6G6D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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