Seroatlas · Human Serome Atlas

LY6G6C

Lymphocyte antigen 6 complex locus protein G6c

Also known as: C6orf24, G6c, LY66C_HUMAN, NG24

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95867
Gene: LY6G6C
Ensembl: ENSG00000204421
Chromosome: 6
Canonical length: 125 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

LY6G6C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>O95867|LY6G6C
     1  MKALMLLTLS VLLCWVSADI RCHSCYKVPV LGCVDRQSCR LEPGQQCLTT HAYLGKMWVF
    61  SNLRCGTPEE PCQEAFNQTN RKLGLTYNTT CCNKDNCNSA GPRPTPALGL VFLTSLAGLG
   121  LWLLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LY6G6C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 554 nTPM

Expression across tissuesHPA

Tissue

skin: 554 nTPM
esophagus: 45 nTPM
vagina: 32 nTPM
cervix: 18 nTPM
breast: 15 nTPM
salivary gland: 12 nTPM

Single-cell type

late spermatids: 8 nCPM
esophageal apical cells: 3.7 nCPM
suprabasal keratinocytes: 2.9 nCPM
early spermatids: 2.6 nCPM
esophageal suprabasal cells: 0.7 nCPM
distal convoluted tubule cells: 0.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.6 nTPM
white matter: 0.3 nTPM
cerebral cortex: 0.2 nTPM
hippocampal formation: 0.2 nTPM
medulla oblongata: 0.1 nTPM
pons: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ly-6 antigen/uPA receptor-like
Snake toxin-like superfamily
u-PAR/Ly-6 domain
Lymphocyte antigen 6 complex locus protein G6c

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LY6G6C as an antibody target. Whether an autoantibody or antibody against LY6G6C could matter depends on whether native LY6G6C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LY6G6C is annotated at the cell surface, where native LY6G6C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LY6G6C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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