Seroatlas · Human Serome Atlas

LY6G5C

Lymphocyte antigen 6 complex locus protein G5c

Also known as: C6orf20, G5c, LY65C_HUMAN, NG33

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SRR4
Gene: LY6G5C
Ensembl: ENSG00000204428
Chromosome: 6
Canonical length: 150 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

LY6G5C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

150 residues, UniProt reviewed canonical sequence.

>Q5SRR4|LY6G5C
     1  MRFMAGPAGS QSLGPLCFHS SPQALYTVLL IVLVMMSLVF GKFVPVNWEP PQPLPFPKYL
    61  RCYRCLLETK ELGCLLGSDI CLTPAGSSCI TLHKKNSSGS DVMVSDCRSK EQMSDCSNTR
   121  TSPVSGFWIF SQYCFLDFCN DPQNRGLYTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LY6G5C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 2.4 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 2.4 nTPM
testis: 1.6 nTPM
basal ganglia: 1.5 nTPM
retina: 1.3 nTPM
pituitary gland: 0.9 nTPM
cerebral cortex: 0.8 nTPM

Single-cell type

platelets: 8.5 nCPM
brain inhibitory neurons: 5.4 nCPM
parietal cells: 5.3 nCPM
oligodendrocyte progenitor cells: 2.6 nCPM
ependymal cells: 2.5 nCPM
respiratory ionocytes: 2.5 nCPM

Immune cell

non-classical monocyte: 1.4 nTPM
eosinophil: 0.9 nTPM
basophil: 0.7 nTPM
T-reg: 0.6 nTPM
plasmacytoid DC: 0.5 nTPM
memory CD8 T-cell: 0.4 nTPM

Brain region

cerebellum: 4.3 nTPM
basal ganglia: 4 nTPM
cerebral cortex: 1.9 nTPM
thalamus: 1.8 nTPM
white matter: 1.6 nTPM
hippocampal formation: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0.41
gnomAD missense Z: 1.34
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ly-6 antigen/uPA receptor-like
u-PAR/Ly-6 domain
Lymphocyte antigen 6 complex locus protein G5c

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LY6G5C as an antibody target. Whether an autoantibody or antibody against LY6G5C could matter depends on whether native LY6G5C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LY6G5C is annotated as secreted, so native LY6G5C circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LY6G5C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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