Seroatlas · Human Serome Atlas

LY6G5B

Lymphocyte antigen 6 complex locus protein G5b

Also known as: C6orf19, G5b, LY65B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NDX9
Gene
LY6G5B
Ensembl
ENSG00000240053
Chromosome
6
Canonical length
201 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

LY6G5B belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>Q8NDX9|LY6G5B
     1  MKVHMLVGVL VMVGFTVGKV PVPDIRTCHF CLVEDPSVGC ISGSEKCTIS SSSLCMVITI
    61  YYDVKVRFIV RGCGQYISYR CQEKRNTYFA EYWYQAQCCQ YDYCNSWSSP QLQSSLPEPH
   121  DRPLALPLSD SQIQWFYQAL NLSLPLPNFH AGTEPDGLDP MVTLSLNLGL SFAELRRMYL
   181  FLNSSGLLVL PQAGLLTPHP S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LY6G5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
59 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 59 nTPM
  • skin: 41 nTPM
  • ovary: 31 nTPM
  • spleen: 29 nTPM
  • adipose tissue: 28 nTPM
  • bone marrow: 28 nTPM

Single-cell type

  • choroid plexus epithelial cells: 10 nCPM
  • astrocytes: 8.8 nCPM
  • bergmann glia: 8 nCPM
  • brain excitatory neurons: 6.5 nCPM
  • oligodendrocytes: 6.4 nCPM
  • brain inhibitory neurons: 6.1 nCPM

Immune cell

  • gdT-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 13 nTPM
  • cerebral cortex: 8 nTPM
  • hypothalamus: 5.8 nTPM
  • basal ganglia: 5.4 nTPM
  • thalamus: 5.3 nTPM
  • white matter: 5.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LY6G5B.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 38 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.64
gnomAD pLI
0
gnomAD missense Z
-0.1
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LY6G5B as an antibody target. Whether an autoantibody or antibody against LY6G5B could matter depends on whether native LY6G5B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LY6G5B is annotated as secreted, so native LY6G5B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LY6G5B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LY6G5B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...