Seroatlas · Human Serome Atlas

LY6D

Lymphocyte antigen 6D

Also known as: E48, LY6D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14210
Gene
LY6D
Ensembl
ENSG00000167656
Chromosome
8
Canonical length
128 aa
Protein class
Plasma proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in lymphocyte differentiation. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

128 residues, UniProt reviewed canonical sequence.

>Q14210|LY6D
     1  MRTALLLLAA LAVATGPALT LRCHVCTSSS NCKHSVVCPA SSRFCKTTNT VEPLRGNLVK
    61  KDCAESCTPS YTLQGQVSSG TSSTQCCQED LCNEKLHNAA PTRTALAHSA LSLGLALSLL
   121  AVILAPSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LY6D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
2,202 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 2,202 nTPM
  • skin: 899 nTPM
  • vagina: 509 nTPM
  • cervix: 498 nTPM
  • salivary gland: 238 nTPM
  • tonsil: 71 nTPM

Single-cell type

  • esophageal suprabasal cells: 15,063 nCPM
  • esophageal apical cells: 7,830 nCPM
  • esophageal basal cells: 7,329 nCPM
  • suprabasal keratinocytes: 4,782 nCPM
  • basal keratinocytes: 1,575 nCPM
  • urothelial cells: 425 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1 nTPM
  • white matter: 0.5 nTPM
  • basal ganglia: 0.3 nTPM
  • amygdala: 0.1 nTPM
  • choroid plexus: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.87
gnomAD pLI
0.03
gnomAD missense Z
0.61
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LY6D as an antibody target. Whether an autoantibody or antibody against LY6D could matter depends on whether native LY6D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LY6D is annotated at the cell surface, where native LY6D is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LY6D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LY6D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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