Seroatlas · Human Serome Atlas

LVRN

Aminopeptidase Q

Also known as: AMPQ_HUMAN, APQ, AQPEP, FLJ90650, TAQPEP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6Q4G3
Gene: LVRN
Ensembl: ENSG00000172901
Chromosome: 5
Canonical length: 990 aa
Protein class: Enzymes, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

990 residues, UniProt reviewed canonical sequence.

>Q6Q4G3|LVRN
     1  MGPPSSSGFY VSRAVALLLA GLVAALLLAL AVLAALYGHC ERVPPSELPG LRDLEAESSP
    61  PLRQKPTPTP KPSSARELAV TTTPSNWRPP GPWDQLRLPP WLVPLHYDLE LWPQLRPDEL
   121  PAGSLPFTGR VNITVRCTVA TSRLLLHSLF QDCERAEVRG PLSPGTGNAT VGRVPVDDVW
   181  FALDTEYMVL ELSEPLKPGS SYELQLSFSG LVKEDLREGL FLNVYTDQGE RRALLASQLE
   241  PTFARYVFPC FDEPALKATF NITMIHHPSY VALSNMPKLG QSEKEDVNGS KWTVTTFSTT
   301  PHMPTYLVAF VICDYDHVNR TERGKEIRIW ARKDAIANGS ADFALNITGP IFSFLEDLFN
   361  ISYSLPKTDI IALPSFDNHA MENWGLMIFD ESGLLLEPKD QLTEKKTLIS YVVSHEIGHQ
   421  WFGNLVTMNW WNNIWLNEGF ASYFEFEVIN YFNPKLPRNE IFFSNILHNI LREDHALVTR
   481  AVAMKVENFK TSEIQELFDI FTYSKGASMA RMLSCFLNEH LFVSALKSYL KTFSYSNAEQ
   541  DDLWRHFQMA IDDQSTVILP ATIKNIMDSW THQSGFPVIT LNVSTGVMKQ EPFYLENIKN
   601  RTLLTSNDTW IVPILWIKNG TTQPLVWLDQ SSKVFPEMQV SDSDHDWVIL NLNMTGYYRV
   661  NYDKLGWKKL NQQLEKDPKA IPVIHRLQLI DDAFSLSKNN YIEIETALEL TKYLAEEDEI
   721  IVWHTVLVNL VTRDLVSEVN IYDIYSLLKR YLLKRLNLIW NIYSTIIREN VLALQDDYLA
   781  LISLEKLFVT ACWLGLEDCL QLSKELFAKW VDHPENEIPY PIKDVVLCYG IALGSDKEWD
   841  ILLNTYTNTT NKEEKIQLAY AMSCSKDPWI LNRYMEYAIS TSPFTSNETN IIEVVASSEV
   901  GRYVAKDFLV NNWQAVSKRY GTQSLINLIY TIGRTVTTDL QIVELQQFFS NMLEEHQRIR
   961  VHANLQTIKN ENLKNKKLSA RIAAWLRRNT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LVRN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

placenta: 20 nTPM
adipose tissue: 10 nTPM
breast: 2 nTPM
tongue: 1.1 nTPM
small intestine: 0.8 nTPM
blood vessel: 0.6 nTPM

Single-cell type

adipocytes: 352 nCPM
late spermatids: 123 nCPM
extravillous trophoblasts: 102 nCPM
fibro-adipogenic progenitors: 79 nCPM
corticotrophs: 60 nCPM
early spermatids: 48 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
hippocampal formation: 0.1 nTPM
hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LVRN as an antibody target. Whether an autoantibody or antibody against LVRN could matter depends on whether native LVRN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LVRN is annotated as secreted, so native LVRN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LVRN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...