Seroatlas · Human Serome Atlas

LTB4R2

Leukotriene B4 receptor 2

Also known as: BLT2, BLTR2, JULF2, LT4R2_HUMAN, NOP9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPC1
Gene: LTB4R2
Ensembl: ENSG00000213906
Chromosome: 14
Canonical length: 358 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within keratinocyte migration and signal transduction. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

358 residues, UniProt reviewed canonical sequence.

>Q9NPC1|LTB4R2
     1  MSVCYRPPGN ETLLSWKTSR ATGTAFLLLA ALLGLPGNGF VVWSLAGWRP ARGRPLAATL
    61  VLHLALADGA VLLLTPLFVA FLTRQAWPLG QAGCKAVYYV CALSMYASVL LTGLLSLQRC
   121  LAVTRPFLAP RLRSPALARR LLLAVWLAAL LLAVPAAVYR HLWRDRVCQL CHPSPVHAAA
   181  HLSLETLTAF VLPFGLMLGC YSVTLARLRG ARWGSGRHGA RVGRLVSAIV LAFGLLWAPY
   241  HAVNLLQAVA ALAPPEGALA KLGGAGQAAR AGTTALAFFS SSVNPVLYVF TAGDLLPRAG
   301  PRFLTRLFEG SGEARGGGRS REGTMELRTT PQLKVVGQGR GNGDPGGGME KDGPEWDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LTB4R2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

skin: 45 nTPM
esophagus: 36 nTPM
vagina: 20 nTPM
cervix: 19 nTPM
spleen: 13 nTPM
salivary gland: 11 nTPM

Single-cell type

papillary tip epithelial cells: 0.4 nCPM
podocytes: 0.3 nCPM
cardiomyocytes: 0.2 nCPM
microglia: 0.2 nCPM
vascular smooth muscle cells: 0.2 nCPM
distal convoluted tubule cells: 0.1 nCPM

Immune cell

gdT-cell: 0.7 nTPM
myeloid DC: 0.6 nTPM
classical monocyte: 0.5 nTPM
memory CD4 T-cell: 0.5 nTPM
memory CD8 T-cell: 0.5 nTPM
MAIT T-cell: 0.4 nTPM

Brain region

medulla oblongata: 3.5 nTPM
white matter: 2.7 nTPM
thalamus: 2.5 nTPM
pons: 2.3 nTPM
basal ganglia: 2.2 nTPM
cerebellum: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: -0.3
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
Leukotriene B4 receptor
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
Leukotriene B4 type 2 receptor

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LTB4R2 as an antibody target. Whether an autoantibody or antibody against LTB4R2 could matter depends on whether native LTB4R2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LTB4R2 is annotated at the cell surface, where native LTB4R2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LTB4R2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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