Seroatlas · Human Serome Atlas

LTB4R

Leukotriene B4 receptor 1

Also known as: BLTR, CMKRL1, GPR16, LT4R1_HUMAN, LTB4R1, P2RY7, P2Y7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15722
Gene: LTB4R
Ensembl: ENSG00000213903
Chromosome: 14
Canonical length: 352 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

352 residues, UniProt reviewed canonical sequence.

>Q15722|LTB4R
     1  MNTTSSAAPP SLGVEFISLL AIILLSVALA VGLPGNSFVV WSILKRMQKR SVTALMVLNL
    61  ALADLAVLLT APFFLHFLAQ GTWSFGLAGC RLCHYVCGVS MYASVLLITA MSLDRSLAVA
   121  RPFVSQKLRT KAMARRVLAG IWVLSFLLAT PVLAYRTVVP WKTNMSLCFP RYPSEGHRAF
   181  HLIFEAVTGF LLPFLAVVAS YSDIGRRLQA RRFRRSRRTG RLVVLIILTF AAFWLPYHVV
   241  NLAEAGRALA GQAAGLGLVG KRLSLARNVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF
   301  VAKLLEGTGS EASSTRRGGS LGQTARSGPA ALEPGPSESL TASSPLKLNE LN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LTB4R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 106 nTPM

Expression across tissuesHPA

Tissue

skin: 106 nTPM
esophagus: 99 nTPM
vagina: 50 nTPM
cervix: 46 nTPM
spleen: 40 nTPM
salivary gland: 23 nTPM

Single-cell type

proximal tubule cells: 8.3 nCPM
papillary tip epithelial cells: 6.7 nCPM
ependymal cells: 6 nCPM
microglia: 5.2 nCPM
renal collecting duct intercalated cells: 4.9 nCPM
distal convoluted tubule cells: 3.9 nCPM

Immune cell

neutrophil: 101 nTPM
eosinophil: 41 nTPM
classical monocyte: 39 nTPM
basophil: 17 nTPM
total PBMC: 14 nTPM
myeloid DC: 11 nTPM

Brain region

thalamus: 2.9 nTPM
medulla oblongata: 2.3 nTPM
pons: 2.3 nTPM
white matter: 2.3 nTPM
cerebellum: 2.2 nTPM
choroid plexus: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0.12
gnomAD missense Z: 1.6
DepMap mean gene effect: -0.34
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
Formyl peptide receptor-related
Leukotriene B4 receptor
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
Leukotriene B4 type 1 receptor

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LTB4R as an antibody target. Whether an autoantibody or antibody against LTB4R could matter depends on whether native LTB4R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LTB4R is annotated at the cell surface, where native LTB4R is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LTB4R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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