Seroatlas · Human Serome Atlas

LTB

Lymphotoxin-beta

Also known as: p33, TNFC, TNFC_HUMAN, TNFSF3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q06643
Gene: LTB
Ensembl: ENSG00000227507
Chromosome: 6
Canonical length: 244 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Centrosome

OverviewNCBI Gene

Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>Q06643|LTB
     1  MGALGLEGRG GRLQGRGSLL LAVAGATSLV TLLLAVPITV LAVLALVPQD QGGLVTETAD
    61  PGAQAQQGLG FQKLPEEEPE TDLSPGLPAA HLIGAPLKGQ GLGWETTKEQ AFLTSGTQFS
   121  DAEGLALPQD GLYYLYCLVG YRGRAPPGGG DPQGRSVTLR SSLYRAGGAY GPGTPELLLE
   181  GAETVTPVLD PARRQGYGPL WYTSVGFGGL VQLRRGERVY VNISHPDMVD FARGKTFFGA
   241  VMVG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LTB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 220 nTPM

Expression across tissuesHPA

Tissue

spleen: 220 nTPM
lymph node: 97 nTPM
appendix: 78 nTPM
thymus: 78 nTPM
small intestine: 62 nTPM
tonsil: 45 nTPM

Single-cell type

b-cells: 35 nCPM
innate lymphoid cells: 19 nCPM
pdcs: 12 nCPM
t-cells: 11 nCPM
papillary tip epithelial cells: 5.5 nCPM
neutrophils: 3.7 nCPM

Immune cell

memory B-cell: 1,028 nTPM
naive B-cell: 1,022 nTPM
memory CD4 T-cell: 938 nTPM
naive CD4 T-cell: 727 nTPM
T-reg: 672 nTPM
MAIT T-cell: 649 nTPM

Brain region

medulla oblongata: 0.6 nTPM
basal ganglia: 0.4 nTPM
pons: 0.4 nTPM
thalamus: 0.4 nTPM
cerebral cortex: 0.3 nTPM
choroid plexus: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: 0.79
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LTB as an antibody target. Whether an autoantibody or antibody against LTB could matter depends on whether native LTB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LTB is annotated at the cell surface, where native LTB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LTB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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