Seroatlas · Human Serome Atlas

LTA4H

Leukotriene A-4 hydrolase

Also known as: LKHA4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P09960
Gene
LTA4H
Ensembl
ENSG00000111144
Chromosome
12
Canonical length
611 aa
Protein class
Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

611 residues, UniProt reviewed canonical sequence.

>P09960|LTA4H
     1  MPEIVDTCSL ASPASVCRTK HLHLRCSVDF TRRTLTGTAA LTVQSQEDNL RSLVLDTKDL
    61  TIEKVVINGQ EVKYALGERQ SYKGSPMEIS LPIALSKNQE IVIEISFETS PKSSALQWLT
   121  PEQTSGKEHP YLFSQCQAIH CRAILPCQDT PSVKLTYTAE VSVPKELVAL MSAIRDGETP
   181  DPEDPSRKIY KFIQKVPIPC YLIALVVGAL ESRQIGPRTL VWSEKEQVEK SAYEFSETES
   241  MLKIAEDLGG PYVWGQYDLL VLPPSFPYGG MENPCLTFVT PTLLAGDKSL SNVIAHEISH
   301  SWTGNLVTNK TWDHFWLNEG HTVYLERHIC GRLFGEKFRH FNALGGWGEL QNSVKTFGET
   361  HPFTKLVVDL TDIDPDVAYS SVPYEKGFAL LFYLEQLLGG PEIFLGFLKA YVEKFSYKSI
   421  TTDDWKDFLY SYFKDKVDVL NQVDWNAWLY SPGLPPIKPN YDMTLTNACI ALSQRWITAK
   481  EDDLNSFNAT DLKDLSSHQL NEFLAQTLQR APLPLGHIKR MQEVYNFNAI NNSEIRFRWL
   541  RLCIQSKWED AIPLALKMAT EQGRMKFTRP LFKDLAAFDK SHDQAVRTYQ EHKASMHPVT
   601  AMLVGKDLKV D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LTA4H can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.2
Highest tissue expression
180 nTPM

Expression across tissuesHPA

Tissue

  • lung: 180 nTPM
  • bone marrow: 170 nTPM
  • esophagus: 104 nTPM
  • tonsil: 90 nTPM
  • ovary: 89 nTPM
  • duodenum: 74 nTPM

Single-cell type

  • neutrophil progenitors: 498 nCPM
  • neutrophils: 334 nCPM
  • esophageal apical cells: 313 nCPM
  • monocytes: 285 nCPM
  • esophageal suprabasal cells: 225 nCPM
  • alveolar cells type 2: 211 nCPM

Immune cell

  • intermediate monocyte: 699 nTPM
  • classical monocyte: 663 nTPM
  • non-classical monocyte: 642 nTPM
  • total PBMC: 591 nTPM
  • myeloid DC: 282 nTPM
  • naive B-cell: 158 nTPM

Brain region

  • choroid plexus: 37 nTPM
  • white matter: 36 nTPM
  • cerebellum: 27 nTPM
  • hypothalamus: 25 nTPM
  • thalamus: 22 nTPM
  • medulla oblongata: 21 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LTA4H.

Disease | ImmuneIEDB

Conditions an epitope on LTA4H was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0
gnomAD missense Z
1.48
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LTA4H as an antibody target. Whether an autoantibody or antibody against LTA4H could matter depends on whether native LTA4H is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LTA4H is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LTA4H as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LTA4H. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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