Seroatlas · Human Serome Atlas

LST1

Leukocyte-specific transcript 1 protein

Also known as: B144, D6S49E, LST-1, LST1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00453
Gene: LST1
Ensembl: ENSG00000204482
Chromosome: 6
Canonical length: 97 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

97 residues, UniProt reviewed canonical sequence.

>O00453|LST1
     1  MLSRNDDICI YGGLGLGGLL LLAVVLLSAC LCWLHRRVKR LERSWAQGSS EQELHYASLQ
    61  RLPVPSSEGP DLRGRDKRGT KEDPRADYAC IAENKPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LST1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 181 nTPM

Expression across tissuesHPA

Tissue

spleen: 181 nTPM
bone marrow: 94 nTPM
lung: 49 nTPM
spinal cord: 39 nTPM
midbrain: 25 nTPM
appendix: 21 nTPM

Single-cell type

kupffer cells: 967 nCPM
neutrophils: 550 nCPM
monocytes: 476 nCPM
cdc: 433 nCPM
hofbauer cells: 210 nCPM
macrophages: 204 nCPM

Immune cell

non-classical monocyte: 1,768 nTPM
intermediate monocyte: 1,285 nTPM
neutrophil: 1,151 nTPM
eosinophil: 687 nTPM
total PBMC: 544 nTPM
classical monocyte: 424 nTPM

Brain region

medulla oblongata: 7 nTPM
white matter: 6 nTPM
pons: 5.2 nTPM
hypothalamus: 5.1 nTPM
spinal cord: 4.4 nTPM
thalamus: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
gnomAD missense Z: 0.01
DepMap mean gene effect: -0.37
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Leukocyte-specific transcript 1, LST-1
LST-1 protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LST1 as an antibody target. Whether an autoantibody or antibody against LST1 could matter depends on whether native LST1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LST1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LST1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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