Seroatlas · Human Serome Atlas

LSP1

Lymphocyte-specific protein 1

Also known as: LSP1_HUMAN, WP34

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P33241
Gene: LSP1
Ensembl: ENSG00000130592
Chromosome: 11
Canonical length: 339 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

339 residues, UniProt reviewed canonical sequence.

>P33241|LSP1
     1  MAEASSDPGA EEREELLGPT AQWSVEDEEE AVHEQCQHER DRQLQAQDEE GGGHVPERPK
    61  QEMLLSLKPS EAPELDEDEG FGDWSQRPEQ RQQHEGAQGA LDSGEPPQCR SPEGEQEDRP
   121  GLHAYEKEDS DEVHLEELSL SKEGPGPEDT VQDNLGAAGA EEEQEEHQKC QQPRTPSPLV
   181  LEGTIEQSSP PLSPTTKLID RTESLNRSIE KSNSVKKSQP DLPISKIDQW LEQYTQAIET
   241  AGRTPKLARQ ASIELPSMAV ASTKSRWETG EVQAQSAAKT PSCKDIVAGD MSKKSLWEQK
   301  GGSKTSSTIK STPSGKRYKF VATGHGKYEK VLVEGGPAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LSP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 251 nTPM

Expression across tissuesHPA

Tissue

spleen: 251 nTPM
adrenal gland: 219 nTPM
bone marrow: 158 nTPM
lymph node: 145 nTPM
appendix: 141 nTPM
skin: 102 nTPM

Single-cell type

neutrophils: 79 nCPM
nk-cells: 33 nCPM
monocytes: 31 nCPM
cdc: 28 nCPM
plasma cells: 26 nCPM
thymocytes: 22 nCPM

Immune cell

neutrophil: 1,583 nTPM
total PBMC: 1,293 nTPM
myeloid DC: 899 nTPM
non-classical monocyte: 894 nTPM
intermediate monocyte: 865 nTPM
classical monocyte: 805 nTPM

Brain region

white matter: 25 nTPM
cerebral cortex: 15 nTPM
thalamus: 14 nTPM
medulla oblongata: 13 nTPM
choroid plexus: 12 nTPM
pons: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 0.53
DepMap mean gene effect: 0.03
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

actin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LSP1 as an antibody target. Whether an autoantibody or antibody against LSP1 could matter depends on whether native LSP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LSP1 is annotated at the cell surface, where native LSP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LSP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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