Seroatlas · Human Serome Atlas

LSMEM1

Leucine-rich single-pass membrane protein 1

Also known as: C7orf53, FLJ39575, LSME1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N8F7
Gene
LSMEM1
Ensembl
ENSG00000181016
Chromosome
7
Canonical length
131 aa
Protein class
Predicted membrane proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

131 residues, UniProt reviewed canonical sequence.

>Q8N8F7|LSMEM1
     1  MTHSSQDTGS CGIQEDGKLY VVDSINDLNK LNLCPAGSQH LFPLEDKIPV LGTNSGNGSR
    61  SLFFVGLLIV LIVSLALVFF VIFLIVQTGN KMDDVSRRLT AEGKDIDDLK RINNMIVKRL
   121  NQLNQLDSEQ N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LSMEM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
76 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 76 nTPM
  • tongue: 16 nTPM
  • heart muscle: 1.6 nTPM
  • liver: 1.1 nTPM
  • epididymis: 0.9 nTPM
  • cerebellum: 0.8 nTPM

Single-cell type

  • late spermatids: 39 nCPM
  • early spermatids: 18 nCPM
  • choroid plexus epithelial cells: 9.9 nCPM
  • proximal tubule cells: 9.8 nCPM
  • other brain neurons: 8.4 nCPM
  • astrocytes: 8.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 4.8 nTPM
  • hypothalamus: 4.3 nTPM
  • cerebral cortex: 4.1 nTPM
  • white matter: 3.5 nTPM
  • thalamus: 3.3 nTPM
  • amygdala: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.82
gnomAD pLI
0
gnomAD missense Z
-0.2
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4577
  • Domain of unknown function (DUF4577)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LSMEM1 as an antibody target. Whether an autoantibody or antibody against LSMEM1 could matter depends on whether native LSMEM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LSMEM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LSMEM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LSMEM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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