Seroatlas · Human Serome Atlas

LSAMP

Limbic system-associated membrane protein

Also known as: IGLON3, LAMP, LSAMP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13449
Gene
LSAMP
Ensembl
ENSG00000185565
Chromosome
3
Canonical length
338 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a member of the immunoglobulin LAMP, OBCAM and neurotrimin (IgLON) family of proteins. The encoded preproprotein is proteolytically processed to generate a neuronal surface glycoprotein. This protein may act as a selective homophilic adhesion molecule during axon guidance and neuronal growth in the developing limbic system. The encoded protein may also function as a tumor suppressor and may play a role in neuropsychiatric disorders. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

338 residues, UniProt reviewed canonical sequence.

>Q13449|LSAMP
     1  MVRRVQPDRK QLPLVLLRLL CLLPTGLPVR SVDFNRGTDN ITVRQGDTAI LRCVVEDKNS
    61  KVAWLNRSGI IFAGHDKWSL DPRVELEKRH SLEYSLRIQK VDVYDEGSYT CSVQTQHEPK
   121  TSQVYLIVQV PPKISNISSD VTVNEGSNVT LVCMANGRPE PVITWRHLTP TGREFEGEEE
   181  YLEILGITRE QSGKYECKAA NEVSSADVKQ VKVTVNYPPT ITESKSNEAT TGRQASLKCE
   241  ASAVPAPDFE WYRDDTRINS ANGLEIKSTE GQSSLTVTNV TEEHYGNYTC VAANKLGVTN
   301  ASLVLFRPGS VRGINGSISL AVPLWLLAAS LLCLLSKC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LSAMP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
57 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 57 nTPM
  • retina: 38 nTPM
  • basal ganglia: 36 nTPM
  • amygdala: 34 nTPM
  • hypothalamus: 29 nTPM
  • hippocampal formation: 28 nTPM

Single-cell type

  • astrocytes: 8,317 nCPM
  • bergmann glia: 6,745 nCPM
  • oligodendrocyte progenitor cells: 5,356 nCPM
  • retinal horizontal cells: 4,373 nCPM
  • brain inhibitory neurons: 3,777 nCPM
  • brain excitatory neurons: 3,274 nCPM

Immune cell

  • basophil: 0.9 nTPM
  • naive B-cell: 0.3 nTPM
  • neutrophil: 0.3 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • gdT-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 280 nTPM
  • hippocampal formation: 265 nTPM
  • thalamus: 251 nTPM
  • amygdala: 228 nTPM
  • basal ganglia: 222 nTPM
  • hypothalamus: 210 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
0.99
gnomAD missense Z
1.57
DepMap mean gene effect
0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LSAMP as an antibody target. Whether an autoantibody or antibody against LSAMP could matter depends on whether native LSAMP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LSAMP is annotated at the cell surface, where native LSAMP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LSAMP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LSAMP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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