Seroatlas · Human Serome Atlas

LRRN4CL

LRRN4 C-terminal-like protein

Also known as: LRN4L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8ND94
Gene: LRRN4CL
Ensembl: ENSG00000177363
Chromosome: 11
Canonical length: 238 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

238 residues, UniProt reviewed canonical sequence.

>Q8ND94|LRRN4CL
     1  MLGSPCLLWL LAVTFLVPRA QPLAPQDFEE EEADETETAW PPLPAVPCDY DHCRHLQVPC
    61  KELQRVGPAA CLCPGLSSPA QPPDPPRMGE VRIAAEEGRA VVHWCAPFSP VLHYWLLLWD
   121  GSEAAQKGPP LNATVRRAEL KGLKPGGIYV VCVVAANEAG ASRVPQAGGE GLEGADIPAF
   181  GPCSRLAVPP NPRTLVHAAV GVGTALALLS CAALVWHFCL RDRWGCPRRA AARAAGAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRN4CL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

endometrium: 32 nTPM
adipose tissue: 26 nTPM
ovary: 23 nTPM
cervix: 23 nTPM
fallopian tube: 23 nTPM
breast: 18 nTPM

Single-cell type

fibroblasts: 47 nCPM
decidual stromal cells: 29 nCPM
melanocytes: 26 nCPM
leydig cells: 23 nCPM
myosatellite cells: 23 nCPM
smooth muscle cells: 22 nCPM

Immune cell

neutrophil: 0.6 nTPM
basophil: 0.2 nTPM
classical monocyte: 0.1 nTPM
naive B-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
NK-cell: 0.1 nTPM

Brain region

choroid plexus: 7.5 nTPM
cerebellum: 4.9 nTPM
cerebral cortex: 4.5 nTPM
hypothalamus: 3.4 nTPM
white matter: 3.4 nTPM
hippocampal formation: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRN4CL as an antibody target. Whether an autoantibody or antibody against LRRN4CL could matter depends on whether native LRRN4CL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRN4CL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRN4CL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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