Seroatlas · Human Serome Atlas

LRRN4

Leucine-rich repeat neuronal protein 4

Also known as: C20orf75, dJ1056H1.1, LRRN4_HUMAN, NLRR4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WUT4
Gene: LRRN4
Ensembl: ENSG00000125872
Chromosome: 20
Canonical length: 740 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoli,Nucleoli rim,Mitotic chromosome

OverviewNCBI Gene

Predicted to be involved in long-term memory. Predicted to act upstream of or within visual learning. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

740 residues, UniProt reviewed canonical sequence.

>Q8WUT4|LRRN4
     1  MRQTLPLLLL TVLRPSWADP PQEKVPLFRV TQQGPWGSSG SNATDSPCEG LPAADATALT
    61  LANRNLERLP GCLPRTLRSL DASHNLLRAL STSELGHLEQ LQVLTLRHNR IAALRWGPGG
   121  PAGLHTLDLS YNQLAALPPC TGPALSSLRA LALAGNPLRA LQPRAFACFP ALQLLNLSCT
   181  ALGRGAQGGI AEAAFAGEDG APLVTLEVLD LSGTFLERVE SGWIRDLPKL TSLYLRKMPR
   241  LTTLEGDIFK MTPNLQQLDC QDSPALASVA THIFQDTPHL QVLLFQNCNL SSFPPWTLDS
   301  SQVLSINLFG NPLTCSCDLS WLLTDAKRTV LSRAADTMCA PAAGSSGPFS ASLSLSQLPG
   361  VCQSDQSTTL GASHPPCFNR STYAQGTTVA PSAAPATRPA GDQQSVSKAP NVGSRTIAAW
   421  PHSDAREGTA PSTTNSVAGH SNSSVFPRAA STTRTQHRGE HAPELVLEPD ISAASTPLAS
   481  KLLGPFPTSW DRSISSPQPG QRTHATPQAP NPSLSEGEIP VLLLDDYSEE EEGRKEEVGT
   541  PHQDVPCDYH PCKHLQTPCA ELQRRWRCRC PGLSGEDTIP DPPRLQGVTE TTDTSALVHW
   601  CAPNSVVHGY QIRYSAEGWA GNQSVVGVIY ATARQHPLYG LSPGTTYRVC VLAANRAGLS
   661  QPRSSGWRSP CAAFTTKPSF ALLLSGLCAA SGLLLASTVV LSACLCRRGQ TLGLQRCDTH
   721  LVAYKNPAFD DYPLGLQTVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 9.8 nTPM

Expression across tissuesHPA

Tissue

lung: 9.8 nTPM
adipose tissue: 7.8 nTPM
kidney: 2 nTPM
pancreas: 1.6 nTPM
fallopian tube: 0.9 nTPM
basal ganglia: 0.8 nTPM

Single-cell type

epicardial cells: 71 nCPM
alveolar cells type 1: 50 nCPM
cardiomyocytes: 30 nCPM
mesothelial cells: 26 nCPM
adipocytes: 16 nCPM
oocytes: 14 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 5 nTPM
hypothalamus: 2.4 nTPM
amygdala: 1.5 nTPM
midbrain: 1.4 nTPM
cerebral cortex: 1.3 nTPM
hippocampal formation: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: 0.99
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRN4 as an antibody target. Whether an autoantibody or antibody against LRRN4 could matter depends on whether native LRRN4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRN4 is annotated at the cell surface, where native LRRN4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRN4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...