Seroatlas · Human Serome Atlas

LRRIQ3

Leucine-rich repeat and IQ domain-containing protein 3

Also known as: LRIQ3_HUMAN, LRRC44, MGC22773

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6PVS8
Gene
LRRIQ3
Ensembl
ENSG00000162620
Chromosome
1
Canonical length
624 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane

OverviewNCBI Gene

No narrative summary is available for LRRIQ3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

624 residues, UniProt reviewed canonical sequence.

>A6PVS8|LRRIQ3
     1  MFHGTVTEEL TSHEEWSHYN ENIREGQKDF VFVKFNGLHL KSMENLQSCI SLRVCIFSNN
    61  FITDIHPLQS CIKLIKLDLH GNQIKSLPNT KFWNGLKNLK LLYLHDNGFA KLKNICVLSA
   121  CPTLIALTMF DCPVSLKKGY RHVLVNSIWP LKALDHHVIS DEEIIQNWHL PERFKACNHR
   181  LFFNFCPALR KGTTYEEEIN NIKHITSKIN AILAHNSPVL IVQRWIRGFL VRKNLSPVFF
   241  HKKKQQEKII RGYEAKWIYI TKGYEDKLLK DLFFKPETNI KGKLAYWKHN IYYPVDLKNS
   301  SEHRKHVSSI LCELKPKDLG MKSKTSRHLI QKGQESEDEI VDEKLDTSFR ISVFKLPIYT
   361  SGSLKNNAVL REKKQHFFPA YPQPIYTTHP KPIIKKDIRL ERSMKEFFAP QRAGMKLRTF
   421  SDIDKYYTEQ KKQEYHKEKV RVVAMAQVAR ERVRVAVNEH LNQKKYATQK LIEENKETIQ
   481  NSLRQVWQNR FNYLEKARER KALFLKEKSQ KASERLLVQN LNNERTLLTR GLLKIDRLEK
   541  NEAVLKEKSL IVKQKLKAEK YRKNLLKEMK KVRSQEIYKR HCEEKFVMDM IAFEKACERL
   601  QDAKTKVAIV KTNLDFKVPN GLIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRIQ3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • testis: 19 nTPM
  • fallopian tube: 2 nTPM
  • kidney: 1.9 nTPM
  • choroid plexus: 1.7 nTPM
  • adipose tissue: 1.5 nTPM
  • thyroid gland: 1.4 nTPM

Single-cell type

  • late primary spermatocytes: 475 nCPM
  • early spermatids: 195 nCPM
  • adipocytes: 129 nCPM
  • late spermatids: 123 nCPM
  • early primary spermatocytes: 122 nCPM
  • ependymal cells: 64 nCPM

Immune cell

  • memory B-cell: 1.6 nTPM
  • T-reg: 1.6 nTPM
  • naive CD8 T-cell: 1.3 nTPM
  • MAIT T-cell: 1.1 nTPM
  • memory CD8 T-cell: 1.1 nTPM
  • memory CD4 T-cell: 1 nTPM

Brain region

  • choroid plexus: 2.1 nTPM
  • midbrain: 1.4 nTPM
  • pons: 1.2 nTPM
  • medulla oblongata: 1.1 nTPM
  • thalamus: 1 nTPM
  • white matter: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
-0.82
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRIQ3 as an antibody target. Whether an autoantibody or antibody against LRRIQ3 could matter depends on whether native LRRIQ3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRIQ3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRIQ3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRRIQ3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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