Seroatlas · Human Serome Atlas

LRRCC1

Leucine-rich repeat and coiled-coil domain-containing protein 1

Also known as: CLERC, KIAA1764, LRCC1_HUMAN, VFL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C099
Gene: LRRCC1
Ensembl: ENSG00000133739
Chromosome: 8
Canonical length: 1032 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centrosome

OverviewNCBI Gene

This gene encodes a centrosomal protein that maintains the structural integrity of the centrosome and plays a key role in mitotic spindle formation. The encoded protein contains an N-terminal leucine-rich repeat domain and a C-terminal coiled-coil domain. It associates with the centrosome throughout the cell cycle and accumulates on the mitotic centrosome. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

1032 residues, UniProt reviewed canonical sequence.

>Q9C099|LRRCC1
     1  MEAAAAVVAA EAEVENEDGD SSCGDVCFMD KGLQSISELS LDSTLHAVNL HCNNISKIEA
    61  IDHIWNLQHL DLSSNQISRI EGLNTLTKLC TLNLSCNLIT KVEGLEELIN LTRLNVSYNH
   121  IDDLSGLIPL HGIKHKLRYI DLHSNRIDSI HHLLQCMVGL HFLTNLILEK DGDDNPVCRL
   181  PGYRAVILQT LPQLRILDCK NIFGEPVNLT EINSSQLQCL EGLLDNLVSS DSPLNISEDE
   241  IIDRMPVITA PIDELVPLEQ FASTPSDAVL TSFMSVCQSS EPEKNNHEND LQNEIKLQKL
   301  DDQILQLLNE TSNSIDNVLE KDPRPKRDTD ITSESDYGNR KECNRKVPRR SKIPYDAKTI
   361  QTIKHHNKNY NSFVSCNRKM KPPYLKELYV SSSLANCPML QESEKPKTEI IKVDQSHSED
   421  NTYQSLVEQL DQEREKRWRA EQAENKLMDY IDELHKHANE KEDIHSLALL TTDRLKEIIF
   481  RERNSKGQLE VMVHKLQNEI KKLTVELMKA KDQQEDHLKH LRTLEKTLEK MERQKRQQQA
   541  AQIRLIQEVE LKASAADREI YLLRTSLHRE REQAQQLHQL LALKEQEHRK ELETREFFTD
   601  ADFQDALAKE IAKEEKKHEQ MIKEYQEKID VLSQQYMDLE NEFRIALTVE ARRFQDVKDG
   661  FENVATELAK SKHALIWAQR KENESSSLIK DLTCMVKEQK TKLAEVSKLK QETAANLQNQ
   721  INTLEILIED DKQKSIQIEL LKHEKVQLIS ELAAKESLIF GLRTERKVWG HELAQQGSSL
   781  AQNRGKLEAQ IESLSRENEC LRKTNESDSD ALRIKCKIID DQTETIRKLK DCLQEKDEHI
   841  KRLQEKITEI EKCTQEQLDE KSSQLDEVLE KLERHNERKE KLKQQLKGKE VELEEIRKAY
   901  STLNRKWHDK GELLCHLETQ VKEVKEKFEN KEKKLKAERD KSIELQKNAM EKLHSMDDAF
   961  KRQVDAIVEA HQAEIAQLAN EKQKCIDSAN LKVHQIEKEM RELLEETCKN KKTMEAKIKQ
  1021  LAFALNEIQQ DM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRCC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

testis: 31 nTPM
spinal cord: 12 nTPM
midbrain: 11 nTPM
rectum: 8.5 nTPM
colon: 8.4 nTPM
thyroid gland: 8.2 nTPM

Single-cell type

late primary spermatocytes: 389 nCPM
late spermatids: 247 nCPM
early spermatids: 155 nCPM
early primary spermatocytes: 110 nCPM
erythrocyte progenitors: 96 nCPM
megakaryocyte progenitors: 49 nCPM

Immune cell

T-reg: 1.1 nTPM
myeloid DC: 0.8 nTPM
naive CD8 T-cell: 0.7 nTPM
NK-cell: 0.7 nTPM
memory CD8 T-cell: 0.5 nTPM
plasmacytoid DC: 0.5 nTPM

Brain region

white matter: 6.8 nTPM
medulla oblongata: 6.4 nTPM
basal ganglia: 5.9 nTPM
midbrain: 5.6 nTPM
thalamus: 5.6 nTPM
spinal cord: 5.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LRRCC1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 240 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Joubert syndrome and related disorders

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: 0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell division

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRCC1 as an antibody target. Whether an autoantibody or antibody against LRRCC1 could matter depends on whether native LRRCC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRCC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRCC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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