Seroatlas · Human Serome Atlas

LRRC9

Leucine-rich repeat-containing protein 9

Also known as: FLJ46156, LRRC9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZRR7
Gene: LRRC9
Ensembl: ENSG00000131951
Chromosome: 14
Canonical length: 1453 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Plasma membrane,Cell Junctions

OverviewNCBI Gene

Predicted to enable U2 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1453 residues, UniProt reviewed canonical sequence.

>Q6ZRR7|LRRC9
     1  MIESENLNQE EIIKELCLCN GLSYEMVGQE GSDTSKLEMF FLGYPRIVGL SLFPNLTSLT
    61  IVAQDIKEIS GLEPCLQLKE LWIAECCIEK IEGLQECRNL EKLYLYFNKI SKIENLEKLI
   121  KLKVLWLNHN TIKNIEGLQT LKNLKDLNLA GNLINSIGRC LDSNEQLERL NLSGNQICSF
   181  KELTNLTRLP CLKDLCLNDP QYTTNPVCLL CNYSTHVLYH LPCLQRFDTL DVSAKQIKEL
   241  ADTTAMKKIM YYNMRIKTLQ RHLKEDLEKL NDQKCKLQKL PEERVKLFSF VKKTLERELA
   301  ELKGSGKGHS DGSNNSKVTD PETLKSCETV TEEPSLQQKI LAKLNALNER VTFWNKKLDE
   361  IEAIYHIEVK QKKKSHGLLI PLLLIELETV GNFHFEEGTR SDDWFNFCYE LILSRFCAWD
   421  FRTYGITGVK VKRIIKVNNR ILRLKFEEKF QKFLENEDMH DSESYRRMLE CLFYVFDPEV
   481  SVKKKHLLQI LEKGFKDSET SKLPLKKEAI IVSNSLSISE CPRIEFLQQK HKDEKKISLK
   541  HELFRHGILL ITKVFLGQSV QAHEKESISQ SNYPMVNSVF IPRKYLLNSV MGQRNCDCSV
   601  RQCKWFVFDH DLVLPEYVVE FEYITMVKAP SLFSVFNNVI LEESKKNPEV SVFSKDLKFD
   661  DEVIKMEPRI KARPKLISLD DKTILSLAKT SVYSHIVSLN LHGNSLSKLR DLSKLTGLRK
   721  LNISFNEFTC LDDVYHLYNL EYLDASHNHV ITLEGFRGLM KLKHLDLSWN QLKKSGNEIN
   781  MLCKHTTSLL TLDIQHNPWQ KPATLRLSVI GRLKTLTHLN GVFISEEEAT AAMKFIAGTR
   841  ITQLSLLRHS STKEERPRIL SIWPSAKILT QVSKLGPHLH LSGNCYLKIT ALNLDGQHLF
   901  EITNLEKLEN LKWASFSNNN LTKMEGLESC INLEELTLDG NCISKIEGIS KMTKLTRLSI
   961  NNNLLTGWEE HTFDNMLHLH SLSLENNRIT SLSGLQKSFT LVELYISNNY IAVNQEMHNL
  1021  KGLCNLVILD MCGNIIIWNQ ENYRLFVIFH LPELKALDGI PIEPSETDSA KDLFGGRLTS
  1081  DMIAERQGHS NFKQMQELNW TSSSIRTVDL IPVDQFRNVC NVNLQNNHLT SFSGLIYLPN
  1141  VKVLCLNYNH IESIMPRLKP QTHLTSRQLL YQKVPSSGYG QQGISKTNRD IMSSENLPPI
  1201  MHSLEVLHLG YNGICNLIQL QLNRLRNLKF LFLQGNEISQ VEGLDNLVVL QELVVDHNRI
  1261  RSFNDSAFAK PSSLLALHLE ENRLRELGKL QSLVKLEKLF LGYNKIQDIT ELEKLDVIST
  1321  LRELTVYGNP ICRKMLHRHM LIFRLPNLQM LDGSPVNSDD RAKAEFHLAE LQAKKNSLIP
  1381  VTHSPMDGRS FGQVKTPPIE ITNVLLPSGF SHYLGSDVTL TPEVEEFLGA TFQDQIECNC
  1441  LKRNEHTPRN SPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 5.4 nTPM

Expression across tissuesHPA

Tissue

testis: 5.4 nTPM
choroid plexus: 2.5 nTPM
fallopian tube: 0.8 nTPM
pituitary gland: 0.7 nTPM
prostate: 0.4 nTPM
basal ganglia: 0.3 nTPM

Single-cell type

ependymal cells: 885 nCPM
choroid plexus epithelial cells: 385 nCPM
prostatic glandular cells: 324 nCPM
early spermatids: 251 nCPM
epididymal efferent duct ciliated cells: 196 nCPM
late spermatids: 139 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 15 nTPM
medulla oblongata: 7.5 nTPM
midbrain: 7.3 nTPM
white matter: 6.8 nTPM
spinal cord: 6.2 nTPM
pons: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: 1.7

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC9 as an antibody target. Whether an autoantibody or antibody against LRRC9 could matter depends on whether native LRRC9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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