Seroatlas · Human Serome Atlas

LRRC8B

Volume-regulated anion channel subunit LRRC8B

Also known as: KIAA0231, LRC8B_HUMAN, TA-LRRP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P9F7
Gene: LRRC8B
Ensembl: ENSG00000197147
Chromosome: 1
Canonical length: 803 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Contributes to volume-sensitive anion channel activity. Involved in monoatomic anion transmembrane transport. Located in cytoplasm and plasma membrane. Part of monoatomic ion channel complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

803 residues, UniProt reviewed canonical sequence.

>Q6P9F7|LRRC8B
     1  MITLTELKCL ADAQSSYHIL KPWWDVFWYY ITLIMLLVAV LAGALQLTQS RVLCCLPCKV
    61  EFDNHCAVPW DILKASMNTS SNPGTPLPLP LRIQNDLHRQ QYSYIDAVCY EKQLHWFAKF
   121  FPYLVLLHTL IFAACSNFWL HYPSTSSRLE HFVAILHKCF DSPWTTRALS ETVAEQSVRP
   181  LKLSKSKILL SSSGCSADID SGKQSLPYPQ PGLESAGIES PTSSVLDKKE GEQAKAIFEK
   241  VKRFRMHVEQ KDIIYRVYLK QIIVKVILFV LIITYVPYFL THITLEIDCS VDVQAFTGYK
   301  RYQCVYSLAE IFKVLASFYV ILVILYGLTS SYSLWWMLRS SLKQYSFEAL REKSNYSDIP
   361  DVKNDFAFIL HLADQYDPLY SKRFSIFLSE VSENKLKQIN LNNEWTVEKL KSKLVKNAQD
   421  KIELHLFMLN GLPDNVFELT EMEVLSLELI PEVKLPSAVS QLVNLKELRV YHSSLVVDHP
   481  ALAFLEENLK ILRLKFTEMG KIPRWVFHLK NLKELYLSGC VLPEQLSTMQ LEGFQDLKNL
   541  RTLYLKSSLS RIPQVVTDLL PSLQKLSLDN EGSKLVVLNN LKKMVNLKSL ELISCDLERI
   601  PHSIFSLNNL HELDLRENNL KTVEEIISFQ HLQNLSCLKL WHNNIAYIPA QIGALSNLEQ
   661  LSLDHNNIEN LPLQLFLCTK LHYLDLSYNH LTFIPEEIQY LSNLQYFAVT NNNIEMLPDG
   721  LFQCKKLQCL LLGKNSLMNL SPHVGELSNL THLELIGNYL ETLPPELEGC QSLKRNCLIV
   781  EENLLNTLPL PVTERLQTCL DKC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC8B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 21 nTPM
testis: 14 nTPM
adrenal gland: 14 nTPM
retina: 12 nTPM
spinal cord: 11 nTPM
hippocampal formation: 9.6 nTPM

Single-cell type

adrenal cortex cells: 196 nCPM
platelets: 180 nCPM
late spermatids: 175 nCPM
early spermatids: 174 nCPM
oligodendrocytes: 160 nCPM
lactotrophs: 129 nCPM

Immune cell

T-reg: 1 nTPM
naive CD4 T-cell: 0.9 nTPM
memory B-cell: 0.8 nTPM
naive CD8 T-cell: 0.8 nTPM
classical monocyte: 0.7 nTPM
myeloid DC: 0.7 nTPM

Brain region

white matter: 66 nTPM
cerebral cortex: 62 nTPM
hippocampal formation: 56 nTPM
basal ganglia: 51 nTPM
amygdala: 40 nTPM
spinal cord: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 1
gnomAD missense Z: 2.54
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Leucine-rich repeat
Leucine-rich repeat, typical subtype
LRRC8, pannexin-like TM region
BspA-type LRR region
Leucine-rich repeat domain superfamily
Pannexin-like TM region of LRRC8
BspA type Leucine rich repeat region (6 copies)
Leucine rich repeat
Leucine-rich repeat-containing protein 69/Receptor-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRC8B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

LRRC8A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC8B as an antibody target. Whether an autoantibody or antibody against LRRC8B could matter depends on whether native LRRC8B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC8B is annotated at the cell surface, where native LRRC8B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRC8B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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