Seroatlas · Human Serome Atlas

LRRC75B

Leucine-rich repeat-containing protein 75B

Also known as: C22orf36, FAM211B, LR75B_HUMAN, MGC131773

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2VPJ9
Gene: LRRC75B
Ensembl: ENSG00000178026
Chromosome: 22
Canonical length: 315 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for LRRC75B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q2VPJ9|LRRC75B
     1  MGARLGRRAG PEAGSEAGAA AGCGPAPYER RVRWLREIQS TLRERRPERA RQLLRLLRQD
    61  LGLERTLLPD ILYRDVAFLN PVDPISHDLL VNLARDLQCP KKDYELWKSS DKICRQLIYH
   121  LTPHSKQQQG SSLRQRKTQS CLKSSLQKTL LAGETVDLSG IPLSTQDVQH ITRYLSSHGA
   181  VLAVLDLSFT GLSDELLHLL LPSLWALPRL TQLLLNGNRL TRATARKLTD AIKDTTKFPA
   241  LAWVDLGNNV DVASLPQPLL VGLRRRLSQR TSLPTIYEGL DLEPEGSAAG ATTPASTWDS
   301  TAAGLGPEPQ ACCAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC75B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 8.6 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 8.6 nTPM
testis: 7.5 nTPM
midbrain: 7 nTPM
amygdala: 6.9 nTPM
spinal cord: 6.6 nTPM
cerebral cortex: 6.1 nTPM

Single-cell type

proximal tubule cells: 54 nCPM
enterocytes: 45 nCPM
sertoli cells: 43 nCPM
mucous neck cells: 39 nCPM
cholangiocytes: 36 nCPM
müller glia: 35 nCPM

Immune cell

eosinophil: 0.6 nTPM
NK-cell: 0.5 nTPM
intermediate monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

midbrain: 6.2 nTPM
hypothalamus: 6 nTPM
medulla oblongata: 5.8 nTPM
spinal cord: 5.7 nTPM
thalamus: 5.7 nTPM
amygdala: 5.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.95
gnomAD pLI: 0
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Leucine-rich repeat domain superfamily

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC75B as an antibody target. Whether an autoantibody or antibody against LRRC75B could matter depends on whether native LRRC75B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC75B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC75B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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