Seroatlas · Human Serome Atlas

LRRC75A

Leucine-rich repeat-containing protein 75A

Also known as: C17orf76, FAM211A, FLJ35696, LR75A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NAA5
Gene: LRRC75A
Ensembl: ENSG00000181350
Chromosome: 17
Canonical length: 344 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>Q8NAA5|LRRC75A
     1  MGTRQTKGSL AERASPGAAP GPRRERPDFW ASLLLRAGDK AGRAGAGMPP YHRRVGMVQE
    61  LLRMVRQGRR EEAGTLLQHL RQDLGMESTS LDDVLYRYAS FRNLVDPITH DLIISLARYI
   121  HCPKPEGDAL GAMEKLCRQL TYHLSPHSQW RRHRGLVKRK PQACLKAVLA GSPPDNTVDL
   181  SGIPLTSRDL ERVTSYLQRC GEQVDSVELG FTGLTDDMVL QLLPALSTLP RLTTLALNGN
   241  RLTRAVLRDL TDILKDPSKF PNVTWIDLGN NVDIFSLPQP FLLSLRKRSP KQGHLPTILE
   301  LGEGPGSGEE VREGTVGQED PGGGPVAPAE DHHEGKETVA AAQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC75A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

duodenum: 45 nTPM
small intestine: 42 nTPM
adrenal gland: 20 nTPM
spleen: 20 nTPM
colon: 19 nTPM
bone marrow: 15 nTPM

Single-cell type

epicardial cells: 111 nCPM
parietal cells: 104 nCPM
fallopian secretory cells: 104 nCPM
erythrocyte progenitors: 101 nCPM
megakaryocyte-erythroid progenitors: 95 nCPM
suprabasal keratinocytes: 89 nCPM

Immune cell

naive B-cell: 1.9 nTPM
non-classical monocyte: 1 nTPM
naive CD8 T-cell: 0.7 nTPM
classical monocyte: 0.5 nTPM
NK-cell: 0.4 nTPM
total PBMC: 0.4 nTPM

Brain region

cerebral cortex: 24 nTPM
midbrain: 23 nTPM
hippocampal formation: 22 nTPM
amygdala: 22 nTPM
hypothalamus: 22 nTPM
thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.7
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteasome-mediated ubiquitin-dependent protein catabolic process

Molecular functions

ubiquitin-like ligase-substrate adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Leucine-rich repeat domain superfamily

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC75A as an antibody target. Whether an autoantibody or antibody against LRRC75A could matter depends on whether native LRRC75A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC75A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC75A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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