Seroatlas · Human Serome Atlas

LRRC74B

Leucine-rich repeat-containing protein 74B

Also known as: LR74B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZQY2
Gene
LRRC74B
Ensembl
ENSG00000187905
Chromosome
22
Canonical length
392 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for LRRC74B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

392 residues, UniProt reviewed canonical sequence.

>Q6ZQY2|LRRC74B
     1  MRGSCERSGE DEEQKEEAMV ACGRLSGVPE AEQGPEANWD SDLETEGTDG LGELVRDTLY
    61  LRSCRAHSVV PISCFLRQGS AQELNLRHRG LGPQGARALA SSLSSNPYVK RLDLRDNGLC
   121  GAGAEALAGA LSKSSSIHDV DLSENQLGVA GAQALCAALT VNQAMRKMQL SGNGLEEQAA
   181  QHLAELLLAH TDLKSLDLSY NQLNDQAGET LGPALAENTG LTELNVSWNH LRGPGAVAFA
   241  RGLEANIFLK VLDISYNGFG DPGASAVGEA LKANNVLEEL NMSNNRISAM GALSLGLGLR
   301  VNQTLRILVV SRNPMRSEGC FGLLKSVQDN PASALELLDF SDIQVNAEFD GLASSVRGIL
   361  PELCIKTGAC RVEYKKELLP VFRSALPASV PK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC74B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
2.5 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 2.5 nTPM
  • choroid plexus: 1.6 nTPM
  • testis: 1.2 nTPM
  • lung: 0.9 nTPM
  • basal ganglia: 0.5 nTPM
  • hippocampal formation: 0.5 nTPM

Single-cell type

  • ependymal cells: 333 nCPM
  • choroid plexus epithelial cells: 104 nCPM
  • respiratory ciliated cells: 62 nCPM
  • fallopian tube ciliated cells: 53 nCPM
  • epididymal efferent duct ciliated cells: 50 nCPM
  • endometrial ciliated cells: 40 nCPM

Immune cell

  • basophil: 0.8 nTPM
  • neutrophil: 0.7 nTPM
  • naive B-cell: 0.2 nTPM
  • NK-cell: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • cerebellum: 5.1 nTPM
  • choroid plexus: 5.1 nTPM
  • white matter: 5 nTPM
  • cerebral cortex: 4.4 nTPM
  • thalamus: 4.3 nTPM
  • basal ganglia: 4.2 nTPM

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC74B as an antibody target. Whether an autoantibody or antibody against LRRC74B could matter depends on whether native LRRC74B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC74B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC74B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRRC74B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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