Seroatlas · Human Serome Atlas

LRRC74A

Leucine-rich repeat-containing protein 74A

Also known as: C14orf166B, LR74A_HUMAN, LRRC74

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0VAA2
Gene: LRRC74A
Ensembl: ENSG00000100565
Chromosome: 14
Canonical length: 488 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for LRRC74A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

488 residues, UniProt reviewed canonical sequence.

>Q0VAA2|LRRC74A
     1  MHIQFPSKPT LPRACWEGRI TAGSPGMPPD EIEIEPVRQS SDKMLYCEAE SPPTVEKVKP
    61  ARENSETDLE IEDDEKFFTT GQKELYLEAC KLMGVVPVSY FIRNMEESYV NLNHHGLGPR
   121  GTKAIAIALV SNMAVTKLEL EDNCIMEEGV LSLVEMLQEN YYLQEMNISN NHLGLEGARI
   181  ISDFFERNSS SIWSLELSGN DFKEDSAALL CQALSTNYQI KKLDLSHNQF SDVGGEHLGQ
   241  MLAINVGLTS LDLSWNNFHT RGAVALCNGL RGNVTLTKLD LSMNGFGNEV ALALGEVLRL
   301  NRCLVYLDIG GNDIGNEGAS KISKGLESNE SLRVLKLFLN PINMDGAILL ILAIKRNPKS
   361  RMEELDISNV LVSEQFMKTL DGVYAVHPQL DVVFKAVQGL SPKKTIFLLT NPMKLIQSYA
   421  DQHKITIVDF FKSLNPTGTM KMSVDEFQKV MIEQNKVPLN QYQVREVIKK LDEKTGMVNF
   481  SFLNTMKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC74A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 6.2 nTPM

Expression across tissuesHPA

Tissue

testis: 6.2 nTPM
spleen: 0.3 nTPM
ovary: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

late spermatids: 186 nCPM
early spermatids: 114 nCPM
late primary spermatocytes: 37 nCPM
microglia: 11 nCPM
foveolar cells: 5 nCPM
vascular endothelial cells: 4.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.4 nTPM
medulla oblongata: 0.4 nTPM
pons: 0.4 nTPM
basal ganglia: 0.3 nTPM
midbrain: 0.3 nTPM
thalamus: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC74A as an antibody target. Whether an autoantibody or antibody against LRRC74A could matter depends on whether native LRRC74A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC74A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC74A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...