Seroatlas · Human Serome Atlas

LRRC72

Leucine-rich repeat-containing protein 72

Also known as: CFAP279, FAP279, LRC72_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NJI9
Gene
LRRC72
Ensembl
ENSG00000205858
Chromosome
7
Canonical length
287 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for LRRC72 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

287 residues, UniProt reviewed canonical sequence.

>A6NJI9|LRRC72
     1  MSWDPNPVPR TLRCWRLRRA SETALQSSRR AVEDQLKICG HRRDADVFEL FLSKKELTEV
    61  IDLSRFKKLK YLWLHHNKLH GITFLTRNYC LTELYLNNNA IFEIEGLHYL PSLHILLLHH
   121  NELTNIDATV KELKGMLNLK ILSLYQNPLC QYNLYRLYII YHLPGVELLD RNQVTEKERR
   181  SMITIFNHKK AHIVQSIAFG GKVDASWDPK SPFKQKPAQR VPSDFAFANN VDKTVLDDPE
   241  DAVFVRSMKR SVMTLTSMNW DTVPTREERY LEEEGTETAQ MLTVTLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC72 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
2.4 nTPM

Expression across tissuesHPA

Tissue

  • testis: 2.4 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • early spermatids: 197 nCPM
  • late spermatids: 51 nCPM
  • late primary spermatocytes: 20 nCPM
  • breast myoepithelial cells: 11 nCPM
  • neuroendocrine cells: 2.9 nCPM
  • respiratory ionocytes: 2.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebellum: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM
  • pons: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.3
gnomAD pLI
0
gnomAD missense Z
0.49
DepMap mean gene effect
0.11
DepMap dependency class
selective

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC72 as an antibody target. Whether an autoantibody or antibody against LRRC72 could matter depends on whether native LRRC72 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC72 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC72 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRRC72. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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