Seroatlas · Human Serome Atlas

LRRC71

Leucine-rich repeat-containing protein 71

Also known as: C1orf92, FLJ32884, LRC71_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4P6
Gene: LRRC71
Ensembl: ENSG00000160838
Chromosome: 1
Canonical length: 559 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for LRRC71 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

559 residues, UniProt reviewed canonical sequence.

>Q8N4P6|LRRC71
     1  MSSEQSAPGA SPRAPRPGTQ KSSGAVTKKG ERAAKEKPAT VLPPVGEEEP KSPEEYQCSG
    61  VLETDFAELC TRWGYTDFPK VVNRPRPHPP FVPSASLSEK ATLDDPRLSG SCSLNSLESK
   121  YVFFRPTIQV ELEQEDSKSV KEIYIRGWKV EERILGVFSK CLPPLTQLQA INLWKVGLTD
   181  KTLTTFIELL PLCSSTLRKV SLEGNPLPEQ SYHKLMALDS TIAHLSLRNN NIDDRGAQLL
   241  GQALSTLHSC NRTLVSLNLG FNHIGDEGAG YIADGLRLNR SLLWLSLAHN RIQDKGALKL
   301  AEVLRAFELT HTEVVERRRL LLEKGTQERS RSPSSSRHGD SKTDREKSQM VGISNSALVD
   361  KTDKTQTMKT PKGLGKKKEK SWELAKKEEK LGSGQSPTQG TPKKEDATKA GKGKVTIPEQ
   421  KPSRAKGIKI GSREKRSILL ESELVVEATE VVNPLLEPVE HRDGKVFMPG NKVLLHLNLI
   481  RNRITEVGLE GFLATVQYQM QFSKAKSASK GPVGLLWLSL AKNCFAPQCP AYAIIQELML
   541  PRDPIKAKLR EDEAMAFFP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC71 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

testis: 24 nTPM
fallopian tube: 12 nTPM
choroid plexus: 11 nTPM
lung: 2.3 nTPM
hippocampal formation: 1.8 nTPM
hypothalamus: 1.7 nTPM

Single-cell type

late spermatids: 969 nCPM
early spermatids: 268 nCPM
late primary spermatocytes: 187 nCPM
fallopian tube ciliated cells: 128 nCPM
respiratory ciliated cells: 126 nCPM
ependymal cells: 67 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 19 nTPM
midbrain: 10 nTPM
medulla oblongata: 8.5 nTPM
spinal cord: 8.3 nTPM
pons: 4 nTPM
hypothalamus: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0
gnomAD missense Z: 0.65
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Leucine-rich repeat
Leucine-rich repeat domain superfamily
Leucine Rich repeat
Leucine-rich repeat-containing protein 71

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC71 as an antibody target. Whether an autoantibody or antibody against LRRC71 could matter depends on whether native LRRC71 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC71 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC71 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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