Seroatlas · Human Serome Atlas

LRRC70

Leucine-rich repeat-containing protein 70

Also known as: LOC100130733, LRR70_HUMAN, SLRN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z2Q7
Gene: LRRC70
Ensembl: ENSG00000186105
Chromosome: 5
Canonical length: 622 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Involved in positive regulation of response to cytokine stimulus. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

622 residues, UniProt reviewed canonical sequence.

>Q7Z2Q7|LRRC70
     1  MCGLQFSLPC LRLFLVVTCY LLLLLHKEIL GCSSVCQLCT GRQINCRNLG LSSIPKNFPE
    61  STVFLYLTGN NISYINESEL TGLHSLVALY LDNSNILYVY PKAFVQLRHL YFLFLNNNFI
   121  KRLDPGIFKG LLNLRNLYLQ YNQVSFVPRG VFNDLVSVQY LNLQRNRLTV LGSGTFVGMV
   181  ALRILDLSNN NILRISESGF QHLENLACLY LGSNNLTKVP SNAFEVLKSL RRLSLSHNPI
   241  EAIQPFAFKG LANLEYLLLK NSRIRNVTRD GFSGINNLKH LILSHNDLEN LNSDTFSLLK
   301  NLIYLKLDRN RIISIDNDTF ENMGASLKIL NLSFNNLTAL HPRVLKPLSS LIHLQANSNP
   361  WECNCKLLGL RDWLASSAIT LNIYCQNPPS MRGRALRYIN ITNCVTSSIN VSRAWAVVKS
   421  PHIHHKTTAL MMAWHKVTTN GSPLENTETE NITFWERIPT SPAGRFFQEN AFGNPLETTA
   481  VLPVQIQLTT SVTLNLEKNS ALPNDAASMS GKTSLICTQE VEKLNEAFDI LLAFFILACV
   541  LIIFLIYKVV QFKQKLKASE NSRENRLEYY SFYQSARYNV TASICNTSPN SLESPGLEQI
   601  RLHKQIVPEN EAQVILFEHS AL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC70 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 4.8 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 4.8 nTPM
breast: 4.8 nTPM
placenta: 4.3 nTPM
spleen: 4.2 nTPM
thyroid gland: 3.8 nTPM
bone marrow: 3.4 nTPM

Single-cell type

platelets: 1.4 nCPM
lymphatic endothelial cells: 0.8 nCPM
vascular endothelial cells: 0.7 nCPM
hematopoietic stem cells: 0.5 nCPM
mast cells: 0.5 nCPM
epididymal efferent duct ciliated cells: 0.4 nCPM

Immune cell

NK-cell: 0.7 nTPM
neutrophil: 0.4 nTPM
naive CD4 T-cell: 0.2 nTPM
eosinophil: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

medulla oblongata: 2.4 nTPM
midbrain: 2.4 nTPM
white matter: 2.3 nTPM
spinal cord: 2 nTPM
choroid plexus: 1.9 nTPM
cerebral cortex: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 2.52
DepMap mean gene effect: 0.2
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of response to cytokine stimulus

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC70 as an antibody target. Whether an autoantibody or antibody against LRRC70 could matter depends on whether native LRRC70 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC70 is annotated at the cell surface, where native LRRC70 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRC70 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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