Seroatlas · Human Serome Atlas

LRRC61

Leucine-rich repeat-containing protein 61

Also known as: FLJ31392, HSPC295, LRC61_HUMAN, MGC3036

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BV99
Gene: LRRC61
Ensembl: ENSG00000127399
Chromosome: 7
Canonical length: 259 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable alpha-tubulin binding activity and dynein heavy chain binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

259 residues, UniProt reviewed canonical sequence.

>Q9BV99|LRRC61
     1  MDPPAEKPGE AGGLQITPQL LKSRTGEFSL ESILLLKLRG LGLADLGCLG ECLGLEWLDL
    61  SGNALTHLGP LASLRQLAVL NVSNNRLTGL EPLATCENLQ SLNAAGNLLA TPGQLQCLAG
   121  LPCLEYLRLR DPLARLSNPL CANPSYWAAV RELLPGLKVI DGERVIGRGS EFYQLCRDLD
   181  SSLRPSSSPG PRATEAQPWV EPGYWESWPS RSSSILEEAC RQFQDTLQEC WDLDRQASDS
   241  LAQAEQVLSS AGPTSSFVF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC61 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

liver: 24 nTPM
adrenal gland: 18 nTPM
hypothalamus: 16 nTPM
ovary: 15 nTPM
fallopian tube: 14 nTPM
pituitary gland: 13 nTPM

Single-cell type

renal collecting duct principal cells: 14 nCPM
loop of henle epithelial cells: 13 nCPM
renal collecting duct intercalated cells: 12 nCPM
papillary tip epithelial cells: 9.1 nCPM
renal connecting tubule cells: 7 nCPM
proximal tubule cells: 6.9 nCPM

Immune cell

plasmacytoid DC: 18 nTPM
neutrophil: 13 nTPM
T-reg: 13 nTPM
gdT-cell: 11 nTPM
naive B-cell: 11 nTPM
memory B-cell: 8.7 nTPM

Brain region

hypothalamus: 22 nTPM
pons: 17 nTPM
midbrain: 16 nTPM
medulla oblongata: 16 nTPM
choroid plexus: 15 nTPM
basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0
gnomAD missense Z: 0.24
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

outer dynein arm assembly

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC61 as an antibody target. Whether an autoantibody or antibody against LRRC61 could matter depends on whether native LRRC61 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC61 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC61 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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