Seroatlas · Human Serome Atlas

LRRC58

Leucine-rich repeat-containing protein 58

Also known as: LRC58_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96CX6
Gene: LRRC58
Ensembl: ENSG00000163428
Chromosome: 3
Canonical length: 371 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in intracellular signal transduction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

371 residues, UniProt reviewed canonical sequence.

>Q96CX6|LRRC58
     1  MEEAGAAVVT AGEAELNWSR LSVSTETLES ELEARGEERR GAREALLRLL LPHNRLVSLP
    61  RALGSGFPHL QLLDVSGNAL TALGPELLAL RGLRTLLAKN NRLGGPSALP KGLAQSPLCR
   121  SLQVLNLSGN CFQEVPASLL ELRALQTLSL GGNQLQSIPA EIENLQSLEC LYLGGNFIKE
   181  IPPELGNLPS LNYLVLCDNK IQSIPPQLSQ LHSLRSLSLH NNLLTYLPRE ILNLIHLEEL
   241  SLRGNPLVVR FVRDLTYDPP TLLELAARTI KIRNISYTPY DLPGNLLRYL GSASNCPNPK
   301  CGGVYFDCCV RQIKFVDFCG KYRLPLMHYL CSPECSSPCS SASHSSTSQS ESDSEDEASV
   361  AARRMQKVLL G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC58 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 22 nTPM
kidney: 14 nTPM
thyroid gland: 13 nTPM
parathyroid gland: 13 nTPM
ovary: 13 nTPM
thymus: 11 nTPM

Single-cell type

adrenal cortex cells: 168 nCPM
monocyte progenitors: 86 nCPM
alveolar cells type 1: 72 nCPM
megakaryocyte-erythroid progenitors: 71 nCPM
neutrophil progenitors: 67 nCPM
erythrocyte progenitors: 67 nCPM

Immune cell

naive CD4 T-cell: 3.5 nTPM
plasmacytoid DC: 2.8 nTPM
MAIT T-cell: 2.7 nTPM
classical monocyte: 2.6 nTPM
myeloid DC: 2.6 nTPM
naive CD8 T-cell: 2.6 nTPM

Brain region

white matter: 32 nTPM
medulla oblongata: 28 nTPM
basal ganglia: 26 nTPM
midbrain: 26 nTPM
cerebellum: 25 nTPM
spinal cord: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 1.5
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intracellular signal transduction

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC58 as an antibody target. Whether an autoantibody or antibody against LRRC58 could matter depends on whether native LRRC58 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC58 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC58 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...