Seroatlas · Human Serome Atlas

LRRC55

Leucine-rich repeat-containing protein 55

Also known as: FLJ45686, LRC55_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZSA7
Gene: LRRC55
Ensembl: ENSG00000183908
Chromosome: 11
Canonical length: 298 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Involved in positive regulation of voltage-gated potassium channel activity and potassium ion transmembrane transport. Part of voltage-gated potassium channel complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

298 residues, UniProt reviewed canonical sequence.

>Q6ZSA7|LRRC55
     1  MGDTWAQLPW PGPPHPAMLL ISLLLAAGLM HSDAGTSCPV LCTCRNQVVD CSSQRLFSVP
    61  PDLPMDTRNL SLAHNRITAV PPGYLTCYME LQVLDLHNNS LMELPRGLFL HAKRLAHLDL
   121  SYNNFSHVPA DMFQEAHGLV HIDLSHNPWL RRVHPQAFQG LMQLRDLDLS YGGLAFLSLE
   181  ALEGLPGLVT LQIGGNPWVC GCTMEPLLKW LRNRIQRCTA DSQLAECRGP PEVEGAPLFS
   241  LTEESFKACH LTLTLDDYLF IAFVGFVVSI ASVATNFLLG ITANCCHRWS KASEEEEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC55 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 3.7 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 3.7 nTPM
hypothalamus: 3.6 nTPM
midbrain: 3.3 nTPM
lymph node: 1.9 nTPM
spinal cord: 1.5 nTPM
hippocampal formation: 1.4 nTPM

Single-cell type

other brain neurons: 6 nCPM
brain inhibitory neurons: 3.2 nCPM
brain excitatory neurons: 2.4 nCPM
endometrial secretory cells: 1.9 nCPM
fallopian secretory cells: 1.4 nCPM
podocytes: 1 nCPM

Immune cell

basophil: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 36 nTPM
midbrain: 28 nTPM
spinal cord: 21 nTPM
white matter: 17 nTPM
hypothalamus: 17 nTPM
thalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0.04
gnomAD missense Z: 0.44
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRC55 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KCNMA1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC55 as an antibody target. Whether an autoantibody or antibody against LRRC55 could matter depends on whether native LRRC55 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC55 is annotated at the cell surface, where native LRRC55 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRC55 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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