Seroatlas · Human Serome Atlas

LRRC51

Leucine-rich repeat-containing protein 51

Also known as: LRC51_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96E66
Gene: LRRC51
Ensembl: ENSG00000184154
Chromosome: 11
Canonical length: 192 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Microtubules

OverviewNCBI Gene

This gene belongs to the leucine-rich repeat containing family. The encoded protein contains a transmembrane domain and two leucine-rich repeat domains. Unlike in mouse and other mammals, readthrough transcription is observed in primates between this gene and the adjacent transmembrane O-methyltransferase (Tomt) gene. Previously, this locus was annotated as a single gene representing the readthrough transcripts as well as the two different transcript species that encoded different proteins. It has since been split into three genes, including the two stand-alone genes and a third gene representing the readthrough transcription. [provided by RefSeq, Feb 2022]

Canonical amino-acid sequenceUniProt

192 residues, UniProt reviewed canonical sequence.

>Q96E66|LRRC51
     1  MNKRDYMNTS VQEPPLDYSF RSIHVIQDLV NEEPRTGLRP LKRSKSGKSL TQSLWLNNNV
    61  LNDLRDFNQV ASQLLEHPEN LAWIDLSFND LTSIDPVLTT FFNLSVLYLH GNSIQRLGEV
   121  NKLAVLPRLR SLTLHGNPME EEKGYRQYVL CTLSRITTFD FSGVTKADRT TAEVWKRMNI
   181  KPKKAWTKQN TL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC51 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 93 nTPM

Expression across tissuesHPA

Tissue

testis: 93 nTPM
fallopian tube: 63 nTPM
choroid plexus: 34 nTPM
amygdala: 19 nTPM
retina: 19 nTPM
basal ganglia: 19 nTPM

Single-cell type

late spermatids: 3,297 nCPM
early spermatids: 502 nCPM
late primary spermatocytes: 212 nCPM
fallopian tube ciliated cells: 39 nCPM
respiratory ciliated cells: 34 nCPM
endometrial ciliated cells: 25 nCPM

Immune cell

NK-cell: 6.8 nTPM
neutrophil: 5.7 nTPM
T-reg: 4 nTPM
eosinophil: 3.3 nTPM
naive B-cell: 3.2 nTPM
memory B-cell: 3.1 nTPM

Brain region

midbrain: 35 nTPM
choroid plexus: 33 nTPM
spinal cord: 31 nTPM
medulla oblongata: 31 nTPM
basal ganglia: 27 nTPM
white matter: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: 0.14
DepMap dependency class: none

OntologyGO

Cellular components

axoneme

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC51 as an antibody target. Whether an autoantibody or antibody against LRRC51 could matter depends on whether native LRRC51 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC51 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC51 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...