Seroatlas · Human Serome Atlas

LRRC47

Leucine-rich repeat-containing protein 47

Also known as: KIAA1185, LRC47_HUMAN, RP1-286D6.3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N1G4
Gene: LRRC47
Ensembl: ENSG00000130764
Chromosome: 1
Canonical length: 583 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

583 residues, UniProt reviewed canonical sequence.

>Q8N1G4|LRRC47
     1  MAAAAVSESW PELELAERER RRELLLTGPG LEERVRAAGG QLPPRLFTLP LLHYLEVSGC
    61  GSLRAPGPGL AQGLPQLHSL VLRRNALGPG LSPELGPLPA LRVLDLSGNA LEALPPGQGL
   121  GPAEPPGLPQ LQSLNLSGNR LRELPADLAR CAPRLQSLNL TGNCLDSFPA ELFRPGALPL
   181  LSELAAADNC LRELSPDIAH LASLKTLDLS NNQLSEIPAE LADCPKLKEI NFRGNKLRDK
   241  RLEKMVSGCQ TRSILEYLRV GGRGGGKGKG RAEGSEKEES RRKRRERKQR REGGDGEEQD
   301  VGDAGRLLLR VLHVSENPVP LTVRVSPEVR DVRPYIVGAV VRGMDLQPGN ALKRFLTSQT
   361  KLHEDLCEKR TAATLATHEL RAVKGPLLYC ARPPQDLKIV PLGRKEAKAK ELVRQLQLEA
   421  EEQRKQKKRQ SVSGLHRYLH LLDGNENYPC LVDADGDVIS FPPITNSEKT KVKKTTSDLF
   481  LEVTSATSLQ ICKDVMDALI LKMAEMKKYT LENKEEGSLS DTEADAVSGQ LPDPTTNPSA
   541  GKDGPSLLVV EQVRVVDLEG SLKVVYPSKA DLATAPPHVT VVR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC47 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 67 nTPM
heart muscle: 26 nTPM
tongue: 24 nTPM
cerebellum: 24 nTPM
liver: 23 nTPM
pancreas: 22 nTPM

Single-cell type

cytotrophoblasts: 72 nCPM
migrating cytotrophoblasts: 58 nCPM
esophageal basal cells: 55 nCPM
syncytiotrophoblasts: 52 nCPM
esophageal suprabasal cells: 49 nCPM
differentiating spermatogonia: 46 nCPM

Immune cell

basophil: 3.7 nTPM
memory CD8 T-cell: 3.6 nTPM
myeloid DC: 3.5 nTPM
intermediate monocyte: 3.3 nTPM
NK-cell: 3.1 nTPM
naive CD8 T-cell: 3 nTPM

Brain region

medulla oblongata: 36 nTPM
white matter: 33 nTPM
cerebral cortex: 32 nTPM
hypothalamus: 32 nTPM
pons: 32 nTPM
midbrain: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.87
gnomAD missense Z: 1.03
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

phenylalanyl-tRNA aminoacylation

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC47 as an antibody target. Whether an autoantibody or antibody against LRRC47 could matter depends on whether native LRRC47 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC47 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC47 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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