Seroatlas · Human Serome Atlas

LRRC43

Leucine-rich repeat-containing protein 43

Also known as: LRC43_HUMAN, MGC35140

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N309
Gene: LRRC43
Ensembl: ENSG00000158113
Chromosome: 12
Canonical length: 656 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

No narrative summary is available for LRRC43 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

656 residues, UniProt reviewed canonical sequence.

>Q8N309|LRRC43
     1  MEASYESESE SESEAGPGTQ RPGTGTVSAA VREHLRKLCL REFPCGAGSW NKSRFLPQTW
    61  RTWRELVPRE EDVVSPGEET VEALLGLVRS RHSPWALLNN SNAEDSFLRE LAIRNPLTIT
   121  DTFFYSYFRS LRVIDKKVTL VDKDLLKFLK LEELVLSANR IKEVDATNLP PTLKVLELYG
   181  NEISSMECLC AHPPAGLQHL GLGHNKLLGP LESLYVTANH WPNLVSLDLG FNDLTDLQSM
   241  VTSLRTLRHL RLLVLQGNPL ALVPYYRGLT IDSLAQLCVL DDITVSPNEK HLFRGLSLNG
   301  DLLAQEAQFV VTIGNIRGVL DTSVLDPEPR PEGPFITYNY YVTYDFVKDE EGEMNESAGV
   361  LAEIVKPSPS LELLVEESPE EVVEDVIEDI VEEVTEEVEG SLESEVEESG ESELSVISGP
   421  STILQMPRAS AEELAKLRLR IDPRLCPSPG TVLFSTAHKP WAEVIPCSYE MQHSLRDLVP
   481  LKAFLLAGTT VTIVEEKILS WPVVLPAVDS PLSAKKGKGE KDKKGKEKDR TGKGEKEPAK
   541  EWKVLKKKKE PPKELRQDPP ILQVLGRGLV ILEPLLAGEP LVSTVCNFGV VRTLTSDRLT
   601  LARDSKKIKK VAKKEKPKAV IPIYEGDYHP EPLTVEVQIQ LNQCRSAEEA LRMFAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 18 nTPM
choroid plexus: 10 nTPM
testis: 6.1 nTPM
basal ganglia: 3.4 nTPM
hypothalamus: 2.2 nTPM
cerebral cortex: 2.1 nTPM

Single-cell type

respiratory ciliated cells: 101 nCPM
fallopian tube ciliated cells: 90 nCPM
late spermatids: 64 nCPM
epididymal efferent duct ciliated cells: 52 nCPM
endometrial ciliated cells: 47 nCPM
cone photoreceptor cells: 37 nCPM

Immune cell

NK-cell: 0.9 nTPM
memory CD8 T-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM
myeloid DC: 0.2 nTPM
non-classical monocyte: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM

Brain region

choroid plexus: 37 nTPM
midbrain: 13 nTPM
spinal cord: 9.8 nTPM
medulla oblongata: 9.7 nTPM
thalamus: 8 nTPM
basal ganglia: 7.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: 0.16
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC43 as an antibody target. Whether an autoantibody or antibody against LRRC43 could matter depends on whether native LRRC43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC43 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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