Seroatlas · Human Serome Atlas

LRRC42

Leucine-rich repeat-containing protein 42

Also known as: LRC42_HUMAN, MGC8974

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y546
Gene: LRRC42
Ensembl: ENSG00000116212
Chromosome: 1
Canonical length: 428 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for LRRC42 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

428 residues, UniProt reviewed canonical sequence.

>Q9Y546|LRRC42
     1  MSYYLSSENH LDPGPIYMRE NGQLHMVNLA LDGVRSSLQK PRPFRLFPKG FSVELCMNRE
    61  DDTARKEKTD HFIFTYTREG NLRYSAKSLF SLVLGFISDN VDHIDSLIGF PEQIAEKLFS
   121  AAEARQKFTE PGAGLRALQK FTEAYGSLVL CSLCLRNRYL VISEKLEEIK SFRELTCLDL
   181  SCCKLGDEHE LLEHLTNEAL SSVTQLHLKD NCLSDAGVRK MTAPVRVMKR GLENLTLLDL
   241  SCNPEITDAG IGYLFSFRKL NCLDISGTGL KDIKTVKHKL QTHIGLVHSK VPLKEFDHSN
   301  CKTEGWADQI VLQWERVTAE AVKPRETSEP RAAAQRFYGK RSRAEAPLKC PLADTHMNSS
   361  EKLQFYKEKA PDCHGPVLKH EAISSQESKK SKKRPFEESE TEQNNSSQPS KQKYVCLAVE
   421  DWDLLNSY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 31 nTPM
adrenal gland: 28 nTPM
pituitary gland: 23 nTPM
liver: 23 nTPM
thyroid gland: 22 nTPM
skin: 21 nTPM

Single-cell type

syncytiotrophoblasts: 65 nCPM
migrating cytotrophoblasts: 56 nCPM
undifferentiated spermatogonia: 51 nCPM
cytotrophoblasts: 51 nCPM
esophageal apical cells: 51 nCPM
basal keratinocytes: 46 nCPM

Immune cell

plasmacytoid DC: 6.9 nTPM
memory CD8 T-cell: 5.9 nTPM
eosinophil: 5.7 nTPM
gdT-cell: 4.9 nTPM
NK-cell: 4.9 nTPM
neutrophil: 4.8 nTPM

Brain region

choroid plexus: 20 nTPM
hypothalamus: 15 nTPM
medulla oblongata: 12 nTPM
basal ganglia: 12 nTPM
cerebral cortex: 11 nTPM
thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: -0.22
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Leucine-rich repeat
Leucine-rich repeat domain superfamily
Leucine Rich repeat
Leucine-rich repeat-containing protein 42

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC42 as an antibody target. Whether an autoantibody or antibody against LRRC42 could matter depends on whether native LRRC42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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