Seroatlas · Human Serome Atlas

LRRC3B

Leucine-rich repeat-containing protein 3B

Also known as: LRC3B_HUMAN, LRP15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96PB8
Gene: LRRC3B
Ensembl: ENSG00000179796
Chromosome: 3
Canonical length: 259 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a tumor suppressor, with lowered expression levels found in gastric, renal, colorectal, lung, and breast cancer tissues. The promoter of this gene is frequently hypermethylated in these cancer tissues, although the hypermethylation does not appear to be the cause of the reduced expression of this gene. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

259 residues, UniProt reviewed canonical sequence.

>Q96PB8|LRRC3B
     1  MNLVDLWLTR SLSMCLLLQS FVLMILCFHS ASMCPKGCLC SSSGGLNVTC SNANLKEIPR
    61  DLPPETVLLY LDSNQITSIP NEIFKDLHQL RVLNLSKNGI EFIDEHAFKG VAETLQTLDL
   121  SDNRIQSVHK NAFNNLKARA RIANNPWHCD CTLQQVLRSM ASNHETAHNV ICKTSVLDEH
   181  AGRPFLNAAN DADLCNLPKK TTDYAMLVTM FGWFTMVISY VVYYVRQNQE DARRHLEYLK
   241  SLPSRQKKAD EPDDISTVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

amygdala: 24 nTPM
cerebral cortex: 23 nTPM
basal ganglia: 23 nTPM
hippocampal formation: 15 nTPM
cerebellum: 14 nTPM
midbrain: 12 nTPM

Single-cell type

astrocytes: 443 nCPM
ependymal cells: 163 nCPM
brain excitatory neurons: 140 nCPM
late primary spermatocytes: 133 nCPM
medullary thymic epithelial cells: 113 nCPM
other brain neurons: 97 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 42 nTPM
cerebral cortex: 32 nTPM
spinal cord: 28 nTPM
hippocampal formation: 26 nTPM
basal ganglia: 23 nTPM
thalamus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0.44
gnomAD missense Z: 2.1
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

signaling receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC3B as an antibody target. Whether an autoantibody or antibody against LRRC3B could matter depends on whether native LRRC3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC3B is annotated at the cell surface, where native LRRC3B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRC3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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