Seroatlas · Human Serome Atlas

LRRC37B

Leucine-rich repeat-containing protein 37B

Also known as: LR37B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96QE4
Gene: LRRC37B
Ensembl: ENSG00000185158
Chromosome: 17
Canonical length: 947 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

947 residues, UniProt reviewed canonical sequence.

>Q96QE4|LRRC37B
     1  MSWLRFWGPW PLLTWQLLSL LVKEAQPLVW VKDPLQLTSN PLGPPEPWSS RSSHLPWESP
    61  HAPAPPAAPG DFDYLGPSAS SQMSALPQEP TENLAPFLKE LDSAGELPLG PEPFLAAHQD
   121  LNDKRTPEER LPEVVPLLNR DQNQALVQLP RLKWVQTTDL DRAAGHQADE ILVPLDSKVS
   181  RPTKFVVSPK NLKKDLAERW SLPEIVGIPH QLSKPQRQKQ TLPDDYLSMD TLYPGSLPPE
   241  LRVNADEPPG PPEQVGLSQF HLEPKSQNPE TLEDIQSSSL QEEAPAQLLQ LPQEVEPSTQ
   301  QEAPALPPES SMESLAQTPL NHEVTVQPPG EDQAHYNLPK FTVKPADVEV TMTSEPKNET
   361  ESTQAQQEAP IQPPEEAEPS STALRTTDPP PEHPEVTLPP SDKGQAQHSH LTEATVQPLD
   421  LELSITTEPT TEVKPSPTTE ETSAQPPDPG LAITPEPTTE IGHSTALEKT RAPHPDQVQT
   481  LHRSLTEVTG PPTKLESSQD SLVQSETAPE EQKASTSTNI CELCTCGDET LSCVGLSPKQ
   541  RLRQVPVPEP DTYNGIFTTL NFQGNYISYL DGNVWKAYSW TEKLILSENY LTELPKDSFE
   601  GLLYLQYLDL SCNKIRYIER QTFESLPFLQ YINLGCNLIT KLSLGTFQAW HGMQFLHNLI
   661  LNRNPLTTVE DPYLFELPAL KYLDMGTTHI TLTTLKNILT MTVELEKLIL PSHMACCLCQ
   721  FKNSIEAVCK TVKLHCNTAC LTNSIHCPEE ASVGNPEGAF MKMLQARKQH MSTQLTIESE
   781  APSDSSGINL SGFGGDQLEI QLTEQLRSLI PNEDVRKFMS HVIRTLKMEC SETHVQGSCA
   841  KLMLRTGLLM KLLSEQQEAK ALNVEWDTDQ QKTNYINENM EQNEQKEQKS SELMKEVPGD
   901  DYKNKLIFAI SVTVILIILI IIFCLIEVNS HKRASEKYKD NPSISGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC37B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 20 nTPM
cerebellum: 17 nTPM
testis: 16 nTPM
hippocampal formation: 9.4 nTPM
thymus: 8.7 nTPM
cerebral cortex: 8.5 nTPM

Single-cell type

early spermatids: 110 nCPM
gonadotrophs: 81 nCPM
oligodendrocyte progenitor cells: 69 nCPM
brain excitatory neurons: 64 nCPM
corticotrophs: 59 nCPM
astrocytes: 56 nCPM

Immune cell

NK-cell: 5.2 nTPM
T-reg: 3 nTPM
eosinophil: 2 nTPM
memory CD8 T-cell: 1.8 nTPM
naive CD4 T-cell: 1.7 nTPM
memory CD4 T-cell: 1.5 nTPM

Brain region

cerebellum: 41 nTPM
hippocampal formation: 29 nTPM
cerebral cortex: 28 nTPM
amygdala: 26 nTPM
basal ganglia: 25 nTPM
white matter: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.01
gnomAD missense Z: 0.1
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC37B as an antibody target. Whether an autoantibody or antibody against LRRC37B could matter depends on whether native LRRC37B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC37B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC37B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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