Seroatlas · Human Serome Atlas

LRRC37A3

Leucine-rich repeat-containing protein 37A3

Also known as: FLJ34306, KIAA0563, L37A3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60309
Gene: LRRC37A3
Ensembl: ENSG00000176809
Chromosome: 17
Canonical length: 1634 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1634 residues, UniProt reviewed canonical sequence.

>O60309|LRRC37A3
     1  MTSAQCPALA CVMSPLRFWG PWPLLMWQLL WLLVKEAQPL EWVKDPLQLT SNPLGPPEPW
    61  SSHSSHFPRE SPHAPTLPAD PWDFDHLGPS ASSEMPAPPQ ESTENLVPFL DTWDSAGELP
   121  LEPEQFLASQ QDLKDKLSPQ ERLPVSPKKL KKDPAQRWSL AEIIGIIHQL STPQSQKQTL
   181  QNEYSSTDTP YPGSLPPELR VKSDEPPGPS EQVGPSQFHL EPETQNPETL EDIQSSSLQQ
   241  EAPAQLPQLL EEEPSSMQQE APALPPESSM ESLTLPNHEV SVQPPGEDQA YYHLPNITVK
   301  PADVEVTITS EPTNETESSQ AQQETPIQFP EEVEPSATQQ EAPIEPPVPP MEHELSISEQ
   361  QQPVQPSESS REVESSPTQQ ETPGQPPEHH EVTVSPPGHH QTHHLASPSV SVKPPDVQLT
   421  IAAEPSAEVG TSLVHQEATT RLSGSGNDVE PPAIQHGGPP LLPESSEEAG PLAVQQETSF
   481  QSPEPINNEN PSPTQQEAAA EHPQTAEEGE SSLTHQEAPA QTPEFPNVVV AQPPEHSHLT
   541  QATVQPLDLG FTITPESMTE VELSPTMKET PTQPPKKVVP QLRVYQGVTN PTPGQDQAQH
   601  PVSPSVTVQL LDLGLTITPE PTTEVGHSTP PKRTIVSPKH PEVTLPHPDQ VQTQHSHLTR
   661  ATVQPLDLGF TITPKSMTEV EPSTALMTTA PPPGHPEVTL PPSDKGQAQH SHLTQATVQP
   721  LDLELTITTK PTTEVKPSPT TEETSTQLPD LGLAIIPEPT TETGHSTALE KTTAPRPDRV
   781  QTLHRSLTEV TGPPTELEPA QDSLVQSESY TQNKALTAPE EHKASTSTNI CELCTCGDEM
   841  LSCIDLNPEQ RLRQVPVPEP NTHNGTFTIL NFQGNYISYI DGNVWKAYSW TEKLILRENN
   901  LTELHKDSFE GLLSLQYLDL SCNKIQSIER HTFEPLPFLK FINLSCNVIT ELSFGTFQAW
   961  HGMQFLHKLI LNHNPLTTVE DPYLFKLPAL KYLDMGTTLV PLTTLKNILM MTVELEKLIV
  1021  PSHMACCLCQ FKNSIEAVCK TVKLHCNSAC LTNTTHCPEE ASVGNPEGAF MKVLQARKNY
  1081  TSTELIIEPE EPSDSSGINL SGFGSEQLDT NDESDVTSTL SYILPYFSAV NLDVKSLLLP
  1141  FIKLPTTGNS LAKIQTVGKN RQRLNRVLMG PRSIQKRHFK EVGRQSIRRE QGAQASVENT
  1201  AEEKRLGSPA PRELKQPHTQ QGPEKLAGNA VYTKPSFTQE HKAAVSVLKP FSKGAPSTSS
  1261  PAKALPQVRD RWKDLTHAIS ILESAKARVT NMKTSKPIVH SRKKYRFHKT RSRMTHRTPK
  1321  VKKSPKVRKK SYLSRLMLSN RLPFSAAKSL INSPSQGAFS SLRDLSPQEN PFLEVSAPSE
  1381  HFIENNNTKD TTARNAFEEN VFMENTNMPE GTISENTNYN HPPEADSAGT AFNLGPTVKQ
  1441  TETKWEYNNV GTDLSPEPKS FNYPLLSSPG DQFEIQLTQQ LQSVIPNNNV RRLIAHVIRT
  1501  LKMDCSGAHV QVTCAKLVSR TGHLMKLLSG QQEVKASKIE WDTDQWKTEN YINESTEAQS
  1561  EQKEKSLEFT KELPGYGYTK KLILALIVTG ILTILIILLC LIEICCHRRS LQEDEEGFSR
  1621  DSEAPTEEES EALP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC37A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

testis: 28 nTPM
pituitary gland: 21 nTPM
hypothalamus: 17 nTPM
kidney: 17 nTPM
thyroid gland: 16 nTPM
retina: 14 nTPM

Single-cell type

renal collecting duct principal cells: 185 nCPM
loop of henle epithelial cells: 155 nCPM
distal convoluted tubule cells: 143 nCPM
papillary tip epithelial cells: 143 nCPM
proximal tubule cells: 142 nCPM
renal connecting tubule cells: 125 nCPM

Immune cell

basophil: 2.6 nTPM
NK-cell: 1.3 nTPM
neutrophil: 0.9 nTPM
plasmacytoid DC: 0.8 nTPM
naive B-cell: 0.6 nTPM
eosinophil: 0.5 nTPM

Brain region

cerebellum: 29 nTPM
hypothalamus: 23 nTPM
cerebral cortex: 21 nTPM
medulla oblongata: 21 nTPM
midbrain: 19 nTPM
pons: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: -0.12
DepMap mean gene effect: -0.4
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC37A3 as an antibody target. Whether an autoantibody or antibody against LRRC37A3 could matter depends on whether native LRRC37A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC37A3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC37A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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