Seroatlas · Human Serome Atlas

LRRC37A2

Leucine-rich repeat-containing protein 37A2

Also known as: FLJ45049, L37A2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NM11
Gene: LRRC37A2
Ensembl: ENSG00000238083
Chromosome: 17
Canonical length: 1700 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable ATP binding activity; ATP hydrolysis activity; and metal ion binding activity. Predicted to be involved in SNARE complex disassembly and protein transport. Predicted to be located in cytoplasm and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1700 residues, UniProt reviewed canonical sequence.

>A6NM11|LRRC37A2
     1  MSSAQCPALV CVMSRLRFWG PWPLLMWQLL WLLVKEAQPL EWVKDPLQLT SNPLGPPDSW
    61  SSHSSHFPRE SPHAPTLPAD PWDFDHLGPS ASSEMPAPPQ ESTENLVPFL DTWDSAGEQP
   121  LEPEQFLASQ QDLKDKLSPQ ERLPVSPKKL KKDPAQRWSL AEIIGITRQL STPQSQKQTL
   181  QNEYSSTDTP YPGSLPPELR VKSDEPPGPS EQVGPSQFHL EPETQNPETL EDIQSSSLQQ
   241  EAPAQLPQLL EEEPSSMQQE APALPPESSM ESLTLPNHEV SVQPPGEDQA YYHLPNITVK
   301  PADVEVTITS EPTNETESSQ AQQETPIQFP EEVEPSATQQ EAPIEPPVPP MEHELSISEQ
   361  QQPVQPSESP REVESSPTQQ ETPGQPPEHH EVTVSPPGHH QTHHLASPSV SVKPPDVQLT
   421  IAAEPSAEVG TSLVHQEATT RLSGSGNDVE PPAIQHGGPP LLPESSEEAG PLAVQQETSF
   481  QSPEPINNEN PSPTQQEAAA EHPQTAEEGE SSLTHQEAPA QTPEFPNVVV AQPPEHSHLT
   541  QATVQPLDLG FTITPESKTE VELSPTMKET PTQPPKKVVP QLRVYQGVTN PTPGQDQAQH
   601  PVSPSVTVQL LDLGLTITPE PTTEVGHSTP PKRTIVSPKH PEVTLPHPDQ VQTQHSHLTR
   661  ATVQPLDLGF TITPKSMTEV EPSTALMTTA PPPGHPEVTL PPSDKGQAQH SHLTQATVQP
   721  LDLELTITTK PTTEVKPSPT TEETSTQPPD LGLAIIPEPT TETRHSTALE KTTAPRPDRV
   781  QTLHRSLTEV TGPPTELEPA QDSLVQSESY TQNKALTAPE EHKASTSTNI CELCTCGDEM
   841  LSCIDLNPEQ RLRQVPVPEP NTHNGTFTIL NFQGNYISYI DGNVWKAYSW TEKLILRENN
   901  LTELHKDSFE GLLSLQYLDL SCNKIQSIER HTFEPLPFLK FINLSCNVIT ELSFGTFQAW
   961  HGMQFLHKLI LNHNPLTTVE DPYLFKLPAL KYLDMGTTLV PLTTLKNILM MTVELEKLIL
  1021  PSHMACCLCQ FKNSIEAVCK TVKLHCNSAC LTNTTHCPEE ASVGNPEGAF MKVLQARKNY
  1081  TSTELIVEPE EPSDSSGINL SGFGSEQLDT NDESDFISTL SYILPYFSAV NLDVKSLLLP
  1141  FIKLPTTGNS LAKIQTVGQN RQRVKRVLMG PRSIQKRHFK EVGRQSIRRE QGAQASVENA
  1201  AEEKRLGSPA PREVEQPHTQ QGPEKLAGNA VYTKPSFTQE HKAAVSVLKP FSKGAPSTSS
  1261  PAKALPQVRD RWKDLTHAIS ILESAKARVT NTKTSKPIVH ARKKYRFHKT RSHVTHRTPK
  1321  VKKSPKVRKK SYLSRLMLAN RLPFSAAKSL INSPSQGAFS SLGDLSPQEN PFLEVSAPSE
  1381  HFIENNNTKH TTARNAFEEN DFMENTNMPE GTISENTNYN HPHEADSAGT AFNLGPTVKQ
  1441  TETKWEYNNV GTDLSPEPKS FNYPLLSSPG DQFEIQLTQQ LQSLIPNNNV RRLIAHVIRT
  1501  LKMDCSGAHV QVTCAKLISR TGHLMKLLSG QQEVKASKIE WDTDQWKIEN YINESTEAQS
  1561  EQKEKSLELK KEVPGYGYTD KLILALIVTG ILTILIILFC LIVICCHRRS LQEDEEGFSR
  1621  GIFRFLPWRG CSSRRESQDG LSSFGQPLWF KDMYKPLSAT RINNHAWKLH KKSSNEDKIL
  1681  NRDPGDSEAP TEEEESEALP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC37A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 6.5 nTPM

Expression across tissuesHPA

Tissue

testis: 6.5 nTPM
thymus: 0.7 nTPM
pituitary gland: 0.5 nTPM
tongue: 0.5 nTPM
adipose tissue: 0.4 nTPM
cerebellum: 0.4 nTPM

Single-cell type

renal collecting duct principal cells: 38 nCPM
distal convoluted tubule cells: 38 nCPM
papillary tip epithelial cells: 37 nCPM
epicardial cells: 36 nCPM
loop of henle epithelial cells: 36 nCPM
renal collecting duct intercalated cells: 33 nCPM

Immune cell

basophil: 1.7 nTPM
memory B-cell: 0.6 nTPM
eosinophil: 0.5 nTPM
myeloid DC: 0.5 nTPM
naive B-cell: 0.4 nTPM
classical monocyte: 0.3 nTPM

Brain region

cerebellum: 2.7 nTPM
hypothalamus: 2.5 nTPM
pons: 2.4 nTPM
cerebral cortex: 2.1 nTPM
amygdala: 2 nTPM
basal ganglia: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: -0.38
DepMap mean gene effect: -0.42
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC37A2 as an antibody target. Whether an autoantibody or antibody against LRRC37A2 could matter depends on whether native LRRC37A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC37A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC37A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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