Seroatlas · Human Serome Atlas

LRRC36

Leucine-rich repeat-containing protein 36

Also known as: FLJ11004, LRC36_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q1X8D7
Gene
LRRC36
Ensembl
ENSG00000159708
Chromosome
16
Canonical length
754 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Mitochondria

OverviewNCBI Gene

No narrative summary is available for LRRC36 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

754 residues, UniProt reviewed canonical sequence.

>Q1X8D7|LRRC36
     1  MAEQWELDEE GIRRLGALTL EQPELVESLS LQGSYAGKIH SIGDAFRNFK NLRSLDLSRN
    61  LITSLKGIQY LCSLQDLNLY YNNIPSLVEV SRLQPLPFLK ELDLRLNPVV RKDTDYRLFA
   121  VYTLQTLEKL DDRTVREGER KAAKLHFSQL GNSENFLLEV EKSSREKTMK NCVTGESSAS
   181  KVSANVDSRI EMDSNKGLFI PFPNREIKDS LSTSATQGNG TRDQKLDTFP LGTQTQEVAR
   241  REMPSDNHQE DEFRHYSPRQ STVRSPEKMT REGYQVSFLD NKSSGSSPEK ELIPKPDTFH
   301  LTHDASLSKC LDVGDSSQIH PYQLPSDVGL ENYDSCYSQT LSLHGSLGKR PQRSKNYQEY
   361  SIKPSNDIKT TASHSCGDLL TSLSNPDSST GRLLKLSSDL YATTHFNSDP AVLVNVEQQL
   421  STSLDDLTPA HGSVPNNAVL GNRTTPLRTL LLSPGTSEHR KIFTKRSLSP SKRGFKWKDN
   481  ILANLNLKHG FQDATGSEPL SSDLGSLHGL AGNHSPPISA RTPHVATVLR QLLELVDKHW
   541  NGSGSLLLNK KFLGPARDLL LSLVVPAPSQ PRCCSHPEDT MKAFCRRELE LKEAAQLVPN
   601  DMESLKQKLV RVLEENLILS EKIQQLEEGA AISIVSGQQS HTYDDLLHKN QQLTMQVACL
   661  NQELAQLKKL EKTVAILHES QRSLVVTNEY LLQQLNKEPK GYSGKALLPP EKGHHLGRSS
   721  PFGKSTLSSS SPVAHETGQY LIQSVLDAAP EPGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • testis: 33 nTPM
  • placenta: 5.7 nTPM
  • lung: 4.6 nTPM
  • fallopian tube: 2.8 nTPM
  • rectum: 0.5 nTPM
  • stomach: 0.5 nTPM

Single-cell type

  • early spermatids: 295 nCPM
  • early primary spermatocytes: 170 nCPM
  • late spermatids: 166 nCPM
  • late primary spermatocytes: 145 nCPM
  • retinal ganglion cells: 85 nCPM
  • respiratory ciliated cells: 76 nCPM

Immune cell

  • plasmacytoid DC: 9.8 nTPM
  • basophil: 1.3 nTPM
  • myeloid DC: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • medulla oblongata: 0.9 nTPM
  • hypothalamus: 0.8 nTPM
  • basal ganglia: 0.6 nTPM
  • midbrain: 0.6 nTPM
  • pons: 0.6 nTPM
  • cerebellum: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0
gnomAD missense Z
1.15
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC36 as an antibody target. Whether an autoantibody or antibody against LRRC36 could matter depends on whether native LRRC36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRRC36. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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