Seroatlas · Human Serome Atlas

LRRC32

Transforming growth factor beta activator LRRC32

Also known as: D11S833E, GARP, LRC32_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14392
Gene
LRRC32
Ensembl
ENSG00000137507
Chromosome
11
Canonical length
662 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

662 residues, UniProt reviewed canonical sequence.

>Q14392|LRRC32
     1  MRPQILLLLA LLTLGLAAQH QDKVPCKMVD KKVSCQVLGL LQVPSVLPPD TETLDLSGNQ
    61  LRSILASPLG FYTALRHLDL STNEISFLQP GAFQALTHLE HLSLAHNRLA MATALSAGGL
   121  GPLPRVTSLD LSGNSLYSGL LERLLGEAPS LHTLSLAENS LTRLTRHTFR DMPALEQLDL
   181  HSNVLMDIED GAFEGLPRLT HLNLSRNSLT CISDFSLQQL RVLDLSCNSI EAFQTASQPQ
   241  AEFQLTWLDL RENKLLHFPD LAALPRLIYL NLSNNLIRLP TGPPQDSKGI HAPSEGWSAL
   301  PLSAPSGNAS GRPLSQLLNL DLSYNEIELI PDSFLEHLTS LCFLNLSRNC LRTFEARRLG
   361  SLPCLMLLDL SHNALETLEL GARALGSLRT LLLQGNALRD LPPYTFANLA SLQRLNLQGN
   421  RVSPCGGPDE PGPSGCVAFS GITSLRSLSL VDNEIELLRA GAFLHTPLTE LDLSSNPGLE
   481  VATGALGGLE ASLEVLALQG NGLMVLQVDL PCFICLKRLN LAENRLSHLP AWTQAVSLEV
   541  LDLRNNSFSL LPGSAMGGLE TSLRRLYLQG NPLSCCGNGW LAAQLHQGRV DVDATQDLIC
   601  RFSSQEEVSL SHVRPEDCEK GGLKNINLII ILTFILVSAI LLTTLAACCC VRRQKFNQQY
   661  KA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
102 nTPM

Expression across tissuesHPA

Tissue

  • lung: 102 nTPM
  • adipose tissue: 100 nTPM
  • blood vessel: 92 nTPM
  • breast: 62 nTPM
  • kidney: 60 nTPM
  • heart muscle: 54 nTPM

Single-cell type

  • extravillous trophoblasts: 244 nCPM
  • vascular endothelial cells: 174 nCPM
  • hepatic stellate cells: 65 nCPM
  • vascular smooth muscle cells: 61 nCPM
  • pericytes: 50 nCPM
  • lymphatic endothelial cells: 27 nCPM

Immune cell

  • total PBMC: 4.3 nTPM
  • T-reg: 2.2 nTPM
  • neutrophil: 0.6 nTPM
  • memory B-cell: 0.2 nTPM
  • basophil: 0.1 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • thalamus: 24 nTPM
  • midbrain: 21 nTPM
  • pons: 19 nTPM
  • amygdala: 18 nTPM
  • basal ganglia: 18 nTPM
  • medulla oblongata: 17 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LRRC32.

Disease | AllUniProt

Conditions LRRC32 is implicated in, by any mechanism.

  • Cleft palate, proliferative retinopathy, and developmental delay (CPPRDD) MIM:619074

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 159 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
0.09
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRC32 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC32 as an antibody target. Whether an autoantibody or antibody against LRRC32 could matter depends on whether native LRRC32 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC32 is annotated at the cell surface, where native LRRC32 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRC32 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRRC32. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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