Seroatlas · Human Serome Atlas

LRRC31

Leucine-rich repeat-containing protein 31

Also known as: FLJ23259, LRC31_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UY01
Gene: LRRC31
Ensembl: ENSG00000114248
Chromosome: 3
Canonical length: 552 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for LRRC31 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

552 residues, UniProt reviewed canonical sequence.

>Q6UY01|LRRC31
     1  MSQTRKKTSS EGETKPQTST VNKFLRGSNA ESRKEDNDLK TSDSQPSDWI QKTATSETAK
    61  PLSSEMEWRS SMEKNEHFLQ KLGKKAVNKC LDLNNCGLTT ADMKEMVALL PFLPDLEELD
   121  ISWNGFVGGT LLSITQQMHL VSKLKILRLG SCRLTTDDVQ ALGEAFEMIP ELEELNLSWN
   181  SKVGGNLPLI LQKFQKGSKI QMIELVDCSL TSEDGTFLGQ LLPMLQSLEV LDLSINRDIV
   241  GSLNSIAQGL KSTSNLKVLK LHSCGLSQKS VKILDAAFRY LGELRKLDLS CNKDLGGGFE
   301  DSPAQLVMLK HLQVLDLHQC SLTADDVMSL TQVIPLLSNL QELDLSANKK MGSSSENLLS
   361  RLRFLPALKS LVINNCALES ETFTALAEAS VHLSALEVFN LSWNKCVGGN LKLLLETLKL
   421  SMSLQVLRLS SCSLVTEDVA LLASVIQTGH LAKLQKLDLS YNDSICDAGW TMFCQNVRFL
   481  KELIELDISL RPSNFRDCGQ WFRHLLYAVT KLPQITEIGM KRWILPASQE EELECFDQDK
   541  KRSIHFDHGG FQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC31 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

rectum: 20 nTPM
colon: 16 nTPM
stomach: 9.5 nTPM
small intestine: 9.1 nTPM
duodenum: 7.9 nTPM
salivary gland: 5.9 nTPM

Single-cell type

goblet cells: 58 nCPM
gastric chief cells: 52 nCPM
mucous neck cells: 32 nCPM
parietal cells: 27 nCPM
gastric progenitor cells: 26 nCPM
colonocytes: 19 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
hypothalamus: 0.3 nTPM
medulla oblongata: 0.3 nTPM
basal ganglia: 0.2 nTPM
cerebellum: 0.2 nTPM
midbrain: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: -0.15
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Leucine-rich repeat
Leucine-rich repeat domain superfamily
Leucine Rich repeat
Leucine-rich repeat-containing protein 31

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC31 as an antibody target. Whether an autoantibody or antibody against LRRC31 could matter depends on whether native LRRC31 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC31 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC31 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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