Seroatlas · Human Serome Atlas

LRRC27

Leucine-rich repeat-containing protein 27

Also known as: KIAA1674, LRC27_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C0I9
Gene: LRRC27
Ensembl: ENSG00000148814
Chromosome: 10
Canonical length: 530 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

No narrative summary is available for LRRC27 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>Q9C0I9|LRRC27
     1  MEGSSSYEVP SVAAADLEEG AGQTRSLPAT PSKDVHKGVG GIIFSSSPIL DLSESGLCRL
    61  EEVFRIPSLQ QLHLQRNALC VIPQDFFQLL PNLTWLDLRY NRIKALPSGI GAHQHLKTLL
   121  LERNPIKMLP VELGSVTTLK ALNLRHCPLE FPPQLVVQKG LVAIQRFLRM WAVEHSLPRN
   181  PTSQEAPPVR EMTLRDLPSP GLELSGDHAS NQGAVNAQDP EGAVMKEKAS FLPPVEKPDL
   241  SELRKSADSS ENWPSEEEIR RFWKLRQEIV EHVKADVLGD QLLTRELPPN LKAALNIEKE
   301  LPKPRHVFRR KTASSRSILP DLLSPYQMAI RAKRLEESRA AALRELQEKQ ALMEQQRREK
   361  RALQEWRERA QRMRKRKEEL SKLLPPRRSM VASKIPSATD LIDNRKVPLN PPGKMKPSKE
   421  KSPQASKEMS ALQERNLEEK IKQHVLQMRE QRRFHGQAPL EEMRKAAEDL EIATELQDEV
   481  LKLKLGLTLN KDRRRAALTG NLSLGLPAAQ PQNTFFNTKY GESGNVRRYQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 72 nTPM

Expression across tissuesHPA

Tissue

testis: 72 nTPM
choroid plexus: 15 nTPM
hippocampal formation: 14 nTPM
basal ganglia: 14 nTPM
amygdala: 14 nTPM
cerebral cortex: 14 nTPM

Single-cell type

late spermatids: 1,552 nCPM
early spermatids: 541 nCPM
late primary spermatocytes: 455 nCPM
ependymal cells: 115 nCPM
respiratory ciliated cells: 75 nCPM
fallopian tube ciliated cells: 55 nCPM

Immune cell

plasmacytoid DC: 5.6 nTPM
myeloid DC: 5.2 nTPM
classical monocyte: 4.7 nTPM
basophil: 4.1 nTPM
intermediate monocyte: 4.1 nTPM
naive B-cell: 2.9 nTPM

Brain region

hippocampal formation: 18 nTPM
medulla oblongata: 17 nTPM
choroid plexus: 16 nTPM
midbrain: 16 nTPM
basal ganglia: 16 nTPM
hypothalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: -0.59
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC27 as an antibody target. Whether an autoantibody or antibody against LRRC27 could matter depends on whether native LRRC27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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