Seroatlas · Human Serome Atlas

LRRC26

Leucine-rich repeat-containing protein 26

Also known as: bA350O14.10, LRC26_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2I0M4
Gene: LRRC26
Ensembl: ENSG00000184709
Chromosome: 9
Canonical length: 334 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoli fibrillar center,Plasma membrane

OverviewNCBI Gene

Enables potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Involved in positive regulation of voltage-gated potassium channel activity and potassium ion transmembrane transport. Located in plasma membrane. Part of voltage-gated potassium channel complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>Q2I0M4|LRRC26
     1  MRGPSWSRPR PLLLLLLLLS PWPVWAQVSA TASPSGSLGA PDCPEVCTCV PGGLASCSAL
    61  SLPAVPPGLS LRLRALLLDH NRVRALPPGA FAGAGALQRL DLRENGLHSV HVRAFWGLGA
   121  LQLLDLSANQ LEALAPGTFA PLRALRNLSL AGNRLARLEP AALGALPLLR SLSLQDNELA
   181  ALAPGLLGRL PALDALHLRG NPWGCGCALR PLCAWLRRHP LPASEAETVL CVWPGRLTLS
   241  PLTAFSDAAF SHCAQPLALR DLAVVYTLGP ASFLVSLASC LALGSGLTAC RARRRRLRTA
   301  ALRPPRPPDP NPDPDPHGCA SPADPGSPAA AAQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 286 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 286 nTPM
prostate: 50 nTPM
colon: 11 nTPM
small intestine: 7 nTPM
breast: 6.3 nTPM
stomach: 4.9 nTPM

Single-cell type

goblet cells: 583 nCPM
lacrimal acinar cells: 318 nCPM
salivary acinar cells: 259 nCPM
prostatic glandular cells: 180 nCPM
salivary duct cells: 159 nCPM
gastric chief cells: 131 nCPM

Immune cell

plasmacytoid DC: 118 nTPM
total PBMC: 0.5 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 6.5 nTPM
hypothalamus: 2.1 nTPM
cerebral cortex: 1.9 nTPM
basal ganglia: 1.6 nTPM
spinal cord: 1.3 nTPM
midbrain: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0.01
gnomAD missense Z: -0.55
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRC26 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KCNMA1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC26 as an antibody target. Whether an autoantibody or antibody against LRRC26 could matter depends on whether native LRRC26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC26 is annotated at the cell surface, where native LRRC26 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRC26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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