Seroatlas · Human Serome Atlas

LRRC19

Leucine-rich repeat-containing protein 19

Also known as: FLJ21302, LRC19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H756
Gene: LRRC19
Ensembl: ENSG00000184434
Chromosome: 9
Canonical length: 370 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable signaling receptor activity. Acts upstream of or within positive regulation of non-canonical NF-kappaB signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

370 residues, UniProt reviewed canonical sequence.

>Q9H756|LRRC19
     1  MKVTGITILF WPLSMILLSD KIQSSKREVQ CNFTEKNYTL IPADIKKDVT ILDLSYNQIT
    61  LNGTDTRVLQ TYFLLTELYL IENKVTILHN NGFGNLSSLE ILNICRNSIY VIQQGAFLGL
   121  NKLKQLYLCQ NKIEQLNADV FVPLRSLKLL NLQGNLISYL DVPPLFHLEL ITLYGNLWNC
   181  SCSLFNLQNW LNTSNVTLEN ENITMCSYPN SLQSYNIKTV PHKAECHSKF PSSVTEDLYI
   241  HFQPISNSIF NSSSNNLTRN SEHEPLGKSW AFLVGVVVTV LTTSLLIFIA IKCPIWYNIL
   301  LSYNHHRLEE HEAETYEDGF TGNPSSLSQI PETNSEETTV IFEQLHSFVV DDDGFIEDKY
   361  IDIHELCEEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

kidney: 40 nTPM
colon: 34 nTPM
rectum: 31 nTPM
small intestine: 30 nTPM
duodenum: 22 nTPM
gallbladder: 5.6 nTPM

Single-cell type

colonocytes: 129 nCPM
enterocytes: 98 nCPM
enteric transient amplifying cells: 41 nCPM
epicardial cells: 30 nCPM
cardiomyocytes: 28 nCPM
proximal tubule cells: 28 nCPM

Immune cell

basophil: 0.2 nTPM
naive B-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM

Brain region

choroid plexus: 4.1 nTPM
cerebellum: 2.7 nTPM
white matter: 2.7 nTPM
midbrain: 2.5 nTPM
hypothalamus: 2.4 nTPM
medulla oblongata: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0
gnomAD missense Z: -0.44
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

signaling receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

Cysteine-rich flanking region, C-terminal
Leucine-rich repeat
Leucine-rich repeat, typical subtype
Leucine-rich repeat domain superfamily
Leucine rich repeat
Leucine-rich repeat family 19 TM domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRC19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC19 as an antibody target. Whether an autoantibody or antibody against LRRC19 could matter depends on whether native LRRC19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC19 is annotated at the cell surface, where native LRRC19 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRC19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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