Seroatlas · Human Serome Atlas

LRRC15

Leucine-rich repeat-containing protein 15

Also known as: LIB, LRC15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TF66
Gene
LRRC15
Ensembl
ENSG00000172061
Chromosome
3
Canonical length
581 aa
Protein class
Plasma proteins, Predicted membrane proteins, Transporters
Subcellular location
Vesicles,Plasma membrane

OverviewNCBI Gene

Enables several functions, including fibronectin binding activity; laminin binding activity; and protein sequestering activity. Involved in several processes, including host-mediated suppression of symbiont invasion; negative regulation of protein localization to plasma membrane; and receptor-mediated virion attachment to host cell. Located in collagen-containing extracellular matrix and plasma membrane. Is active in apical plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

581 residues, UniProt reviewed canonical sequence.

>Q8TF66|LRRC15
     1  MPLKHYLLLL VGCQAWGAGL AYHGCPSECT CSRASQVECT GARIVAVPTP LPWNAMSLQI
    61  LNTHITELNE SPFLNISALI ALRIEKNELS RITPGAFRNL GSLRYLSLAN NKLQVLPIGL
   121  FQGLDSLESL LLSSNQLLQI QPAHFSQCSN LKELQLHGNH LEYIPDGAFD HLVGLTKLNL
   181  GKNSLTHISP RVFQHLGNLQ VLRLYENRLT DIPMGTFDGL VNLQELALQQ NQIGLLSPGL
   241  FHNNHNLQRL YLSNNHISQL PPSVFMQLPQ LNRLTLFGNS LKELSPGIFG PMPNLRELWL
   301  YDNHISSLPD NVFSNLRQLQ VLILSRNQIS FISPGAFNGL TELRELSLHT NALQDLDGNV
   361  FRMLANLQNI SLQNNRLRQL PGNIFANVNG LMAIQLQNNQ LENLPLGIFD HLGKLCELRL
   421  YDNPWRCDSD ILPLRNWLLL NQPRLGTDTV PVCFSPANVR GQSLIIINVN VAVPSVHVPE
   481  VPSYPETPWY PDTPSYPDTT SVSSTTELTS PVEDYTDLTT IQVTDDRSVW GMTQAQSGLA
   541  IAAIVIGIVA LACSLAACVG CCCCKKRSQA VLMQMKAPNE C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
6.7 nTPM

Expression across tissuesHPA

Tissue

  • skin: 6.7 nTPM
  • tonsil: 4.6 nTPM
  • breast: 3.5 nTPM
  • rectum: 2.8 nTPM
  • cervix: 2.7 nTPM
  • placenta: 2.1 nTPM

Single-cell type

  • lymphatic endothelial cells: 11 nCPM
  • hepatic stellate cells: 6.5 nCPM
  • fibroblasts: 2.8 nCPM
  • epicardial cells: 2.3 nCPM
  • schwann cells: 2.1 nCPM
  • syncytiotrophoblasts: 0.8 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 0.2 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM
  • pons: 0.1 nTPM
  • spinal cord: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.41
gnomAD pLI
0
gnomAD missense Z
-0.46
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC15 as an antibody target. Whether an autoantibody or antibody against LRRC15 could matter depends on whether native LRRC15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC15 is annotated at the cell surface, where native LRRC15 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRC15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRRC15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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