Seroatlas · Human Serome Atlas

LRRC14B

Leucine-rich repeat-containing protein 14B

Also known as: LR14B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NHZ5
Gene: LRRC14B
Ensembl: ENSG00000185028
Chromosome: 5
Canonical length: 514 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a leucine-rich repeat containing protein that is a member of the PRAME family. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

514 residues, UniProt reviewed canonical sequence.

>A6NHZ5|LRRC14B
     1  MDTMRSLRFI SAEALVSHPQ VARQSLDSVA HNLYPLLFKA SYLLEQAEVT RAVLGRWPLE
    61  EFRLGALLGP GADHPQDLRD RTCRACLEAL VRGLADHVLQ DRSRRRLRVA DLTGIRDVQV
   121  QRCPCGRALG RWGRTQLLAR TCCELQAEPL AAGRPVEVLA DLFVTEGNFE AVVQALRPAG
   181  PAPLRVHCPS FRADSLSPSQ LLHVLRLAGP GALRKLEVVH NVRLHAGHVQ QLLAQVGFPR
   241  LASLTLPTKA FDAPPTYAST PDGEDPLLAS IARELSKMAQ LTELSVAFST LTGKIPTLLG
   301  PLQTPLRVLD LANCALNHTD MAFLADCAHA AHLEVLDLSG HNLVSLYPST FFRLLSQASR
   361  TLRILTLEEC GIVDSHVGML ILGLSPCHRL RQLKFLGNPL SARALRRLFT ALCELPELRC
   421  IEFPVPKDCY PEGAAYPQDE LAMSKFNQQK YDEIAEELRA VLLRADREDI QVSTPLFGSF
   481  DPDIQETSNE LGAFLLQAFK TALENFSRAL KQIE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC14B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 107 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 107 nTPM
heart muscle: 39 nTPM
tongue: 17 nTPM
basal ganglia: 0.9 nTPM
retina: 0.8 nTPM
hypothalamus: 0.6 nTPM

Single-cell type

myonuclei: 15 nCPM
retinal ganglion cells: 12 nCPM
cardiomyocytes: 9.6 nCPM
retinal horizontal cells: 6 nCPM
oocytes: 4.6 nCPM
epicardial cells: 2.3 nCPM

Immune cell

plasmacytoid DC: 1.6 nTPM
naive CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 2.4 nTPM
hypothalamus: 2.2 nTPM
medulla oblongata: 1.9 nTPM
thalamus: 1.9 nTPM
pons: 1.6 nTPM
basal ganglia: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0
gnomAD missense Z: 0.12
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC14B as an antibody target. Whether an autoantibody or antibody against LRRC14B could matter depends on whether native LRRC14B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC14B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC14B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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