Seroatlas · Human Serome Atlas

LRP5L

Low-density lipoprotein receptor-related protein 5-like protein

Also known as: LRP5L_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A4QPB2
Gene: LRP5L
Canonical length: 252 aa

OverviewNCBI Gene

No narrative summary is available for LRP5L in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

252 residues, UniProt reviewed canonical sequence.

>A4QPB2|LRP5L
     1  MEGHVYWTDD EVWAIRRAYL DGSGAQTLIN TKINDPDDIA VNWVARSLYW THTGTEHIEV
    61  TCLNSTSHKI LVSEDMDEPR AIALHPEMGL TYWIDWGENP EIKRANLDRQ ELRVLVNASL
   121  GWPNGLALDL QEGKLYWGDA KTDKIEAISV DETKRQTLLK DKLPHIFRFT LLGDFIYWTA
   181  WQHHSIKRVH KVKANRDVII DQLPDLMGLK AVNVDKVVGT NPHADRNGGA ATCASSRPTQ
   241  PGLAAPSRAW NC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRP5L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0
gnomAD missense Z: -0.67

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Repeat

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRP5L as an antibody target. Whether an autoantibody or antibody against LRP5L could matter depends on whether native LRP5L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRP5L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRP5L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...