Seroatlas · Human Serome Atlas

LRP3

Low-density lipoprotein receptor-related protein 3

Also known as: hLRp105, LRP-3, LRP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75074
Gene
LRP3
Ensembl
ENSG00000130881
Chromosome
19
Canonical length
770 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Lipid droplets

OverviewNCBI Gene

Involved in negative regulation of fat cell differentiation; positive regulation of osteoblast differentiation; and regulation of gene expression. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

770 residues, UniProt reviewed canonical sequence.

>O75074|LRP3
     1  MEKRAAAGLE GAPGARAQLA VVCLVNIFLT GRLSSAVPAL AACSGKLEQH TERRGVIYSP
    61  AWPLNYPPGT NCSWYIQGDR GDMITISFRN FDVEESHQCS LDWLLLGPAA PPRQEAFRLC
   121  GSAIPPAFIS ARDHVWIFFH SDASSSGQAQ GFRLSYIRGK LGQASCQADE FRCDNGKCLP
   181  GPWQCNTVDE CGDGSDEGNC SAPASEPPGS LCPGGTFPCS GARSTRCLPV ERRCDGLQDC
   241  GDGSDEAGCP DLACGRRLGS FYGSFASPDL FGAARGPSDL HCTWLVDTQD SRRVLLQLEL
   301  RLGYDDYVQV YEGLGERGDR LLQTLSYRSN HRPVSLEAAQ GRLTVAYHAR ARSAGHGFNA
   361  TYQVKGYCLP WEQPCGSSSD SDGGSLGDQG CFSEPQRCDG WWHCASGRDE QGCPACPPDQ
   421  YPCEGGSGLC YTPADRCNNQ KSCPDGADEK NCFSCQPGTF HCGTNLCIFE TWRCDGQEDC
   481  QDGSDEHGCL AAVPRKVITA ALIGSLVCGL LLVIALGCAF KLYSLRTQEY RAFETQMTRL
   541  EAEFVRREAP PSYGQLIAQG LIPPVEDFPV YSASQASVLQ NLRTAMRRQM RRHASRRGPS
   601  RRRLGRLWNR LFHRPRAPRG QIPLLTAARP SQTVLGDGFL QPAPGAAPDP PAPLMDTGST
   661  RAAGDRPPSA PGRAPEVGPS GPPLPSGLRD PECRPVDKDR KVCREPLVDG PAPADAPREP
   721  CSAQDPHPQV STASSTLGPH SPEPLGVCRN PPPPCSPMLE ASDDEALLVC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
77 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 77 nTPM
  • hippocampal formation: 76 nTPM
  • cerebral cortex: 74 nTPM
  • amygdala: 71 nTPM
  • ovary: 62 nTPM
  • cerebellum: 40 nTPM

Single-cell type

  • retinal ganglion cells: 39 nCPM
  • brain inhibitory neurons: 31 nCPM
  • brain excitatory neurons: 29 nCPM
  • oligodendrocyte progenitor cells: 27 nCPM
  • other brain neurons: 27 nCPM
  • retinal amacrine cells: 25 nCPM

Immune cell

  • non-classical monocyte: 0.6 nTPM
  • classical monocyte: 0.5 nTPM
  • intermediate monocyte: 0.2 nTPM
  • neutrophil: 0.1 nTPM
  • NK-cell: 0.1 nTPM
  • total PBMC: 0.1 nTPM

Brain region

  • cerebral cortex: 146 nTPM
  • hippocampal formation: 132 nTPM
  • basal ganglia: 118 nTPM
  • amygdala: 114 nTPM
  • thalamus: 89 nTPM
  • midbrain: 77 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
gnomAD missense Z
1.41
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRP3 as an antibody target. Whether an autoantibody or antibody against LRP3 could matter depends on whether native LRP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRP3 is annotated at the cell surface, where native LRP3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...