Seroatlas · Human Serome Atlas

LRP2BP

LRP2-binding protein

Also known as: DKFZp761O0113, LR2BP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2M1
Gene: LRP2BP
Ensembl: ENSG00000109771
Chromosome: 4
Canonical length: 347 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>Q9P2M1|LRP2BP
     1  MKLTSEKLPK NPFYASVSQY AAKNQKFFQW KKEKTDYTHA NLVDKALQLL KERILKGDTL
    61  AYFLRGQLYF EEGWYEEALE QFEEIKEKDH QATYQLGVMY YDGLGTTLDA EKGVDYMKKI
   121  LDSPCPKARH LKFAAAYNLG RAYYEGKGVK RSNEEAERLW LIAADNGNPK ASVKAQSMLG
   181  LYYSTKEPKE LEKAFYWHSE ACGNGNLESQ GALGLMYLYG QGIRQDTEAA LQCLREAAER
   241  GNVYAQGNLV EYYYKMKFFT KCVAFSKRIA DYDEVHDIPM IAQVTDCLPE FIGRGMAMAS
   301  FYHARCLQLG LGITRDETTA KHYYSKACRL NPALADELHS LLIRQRI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRP2BP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

retina: 27 nTPM
pituitary gland: 16 nTPM
cerebellum: 12 nTPM
testis: 10 nTPM
ovary: 8.3 nTPM
hypothalamus: 8.2 nTPM

Single-cell type

ependymal cells: 249 nCPM
epicardial cells: 205 nCPM
bergmann glia: 104 nCPM
retinal bipolar cells: 102 nCPM
cone photoreceptor cells: 101 nCPM
lactotrophs: 90 nCPM

Immune cell

memory B-cell: 0.5 nTPM
plasmacytoid DC: 0.5 nTPM
naive B-cell: 0.4 nTPM
naive CD4 T-cell: 0.3 nTPM
gdT-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM

Brain region

cerebellum: 33 nTPM
medulla oblongata: 27 nTPM
white matter: 24 nTPM
midbrain: 23 nTPM
spinal cord: 23 nTPM
choroid plexus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 0.49
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Sel1-like repeat
Tetratricopeptide-like helical domain superfamily
Tetratricopeptide repeat
Sel1 repeat
LRP2-binding protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRP2BP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

LRP2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRP2BP as an antibody target. Whether an autoantibody or antibody against LRP2BP could matter depends on whether native LRP2BP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRP2BP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRP2BP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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