Seroatlas · Human Serome Atlas

LRP12

Low-density lipoprotein receptor-related protein 12

Also known as: FLJ12929, LRP12_HUMAN, ST7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y561
Gene
LRP12
Ensembl
ENSG00000147650
Chromosome
8
Canonical length
859 aa
Protein class
Disease related genes, Human disease related genes, Predicted membrane proteins
Subcellular location
Nucleoli fibrillar center,Plasma membrane,Mitochondria

OverviewNCBI Gene

This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many cancer cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Canonical amino-acid sequenceUniProt

859 residues, UniProt reviewed canonical sequence.

>Q9Y561|LRP12
     1  MACRWSTKES PRWRSALLLL FLAGVYGNGA LAEHSENVHI SGVSTACGET PEQIRAPSGI
    61  ITSPGWPSEY PAKINCSWFI RANPGEIITI SFQDFDIQGS RRCNLDWLTI ETYKNIESYR
   121  ACGSTIPPPY ISSQDHIWIR FHSDDNISRK GFRLAYFSGK SEEPNCACDQ FRCGNGKCIP
   181  EAWKCNNMDE CGDSSDEEIC AKEANPPTAA AFQPCAYNQF QCLSRFTKVY TCLPESLKCD
   241  GNIDCLDLGD EIDCDVPTCG QWLKYFYGTF NSPNYPDFYP PGSNCTWLID TGDHRKVILR
   301  FTDFKLDGTG YGDYVKIYDG LEENPHKLLR VLTAFDSHAP LTVVSSSGQI RVHFCADKVN
   361  AARGFNATYQ VDGFCLPWEI PCGGNWGCYT EQQRCDGYWH CPNGRDETNC TMCQKEEFPC
   421  SRNGVCYPRS DRCNYQNHCP NGSDEKNCFF CQPGNFHCKN NRCVFESWVC DSQDDCGDGS
   481  DEENCPVIVP TRVITAAVIG SLICGLLLVI ALGCTCKLYS LRMFERRSFE TQLSRVEAEL
   541  LRREAPPSYG QLIAQGLIPP VEDFPVCSPN QASVLENLRL AVRSQLGFTS VRLPMAGRSS
   601  NIWNRIFNFA RSRHSGSLAL VSADGDEVVP SQSTSREPER NHTHRSLFSV ESDDTDTENE
   661  RRDMAGASGG VAAPLPQKVP PTTAVEATVG ACASSSTQST RGGHADNGRD VTSVEPPSVS
   721  PARHQLTSAL SRMTQGLRWV RFTLGRSSSL SQNQSPLRQL DNGVSGREDD DDVEMLIPIS
   781  DGSSDFDVND CSRPLLDLAS DQGQGLRQPY NATNPGVRPS NRDGPCERCG IVHTAQIPDT
   841  CLEVTLKNET SDDEALLLC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRP12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • smooth muscle: 17 nTPM
  • tongue: 16 nTPM
  • endometrium: 15 nTPM
  • heart muscle: 13 nTPM
  • thymus: 12 nTPM
  • cerebral cortex: 11 nTPM

Single-cell type

  • platelets: 177 nCPM
  • brain inhibitory neurons: 106 nCPM
  • brain excitatory neurons: 91 nCPM
  • lactotrophs: 87 nCPM
  • megakaryocyte progenitors: 75 nCPM
  • oligodendrocyte progenitor cells: 75 nCPM

Immune cell

  • basophil: 47 nTPM
  • eosinophil: 5.9 nTPM
  • MAIT T-cell: 1.4 nTPM
  • memory CD4 T-cell: 1 nTPM
  • intermediate monocyte: 0.8 nTPM
  • NK-cell: 0.8 nTPM

Brain region

  • hippocampal formation: 36 nTPM
  • cerebral cortex: 27 nTPM
  • basal ganglia: 25 nTPM
  • hypothalamus: 18 nTPM
  • cerebellum: 17 nTPM
  • amygdala: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LRP12.

Disease | AllUniProt

Conditions LRP12 is implicated in, by any mechanism.

  • Oculopharyngodistal myopathy 1 (OPDM1) MIM:164310
  • Amyotrophic lateral sclerosis 28 (ALS28) MIM:620452

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 129 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Oculopharyngodistal myopathy 1
  • Amyotrophic lateral sclerosis 28

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.26
gnomAD pLI
1
gnomAD missense Z
1.3
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRP12 as an antibody target. Whether an autoantibody or antibody against LRP12 could matter depends on whether native LRP12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRP12 is annotated at the cell surface, where native LRP12 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRP12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRP12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...